Is Porphyromonas gingivalis involved in Parkinson’s disease?

被引：0
作者：
Ingar Olsen
Douglas B. Kell
Etheresia Pretorius
机构：
[1] University of Oslo,Department of Oral Biology, Faculty of Dentistry
[2] University of Liverpool,Department of Biochemistry, Institute of Integrative Biology, Faculty of Health and Life Sciences
[3] Stellenbosch University,Department of Physiological Sciences, Faculty of Science
来源：
European Journal of Clinical Microbiology & Infectious Diseases | 2020年 / 39卷
关键词：
Systemic inflammation; Cytokines; Hypercoagulation; Amyloid formation; Gingipains; LPS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Porphyromonas gingivalis, a major subgingival plaque bacterium in periodontitis, has recently attracted much attention as a possible microbial driver in Alzheimer’s disease. In the present paper, another common neuroinflammatory disease, Parkinson’s disease (PD), is discussed. A recent study found major virulence factors of P. gingivalis such as gingipain R1 (RgpA) and lipopolysaccharide in the blood circulation of a PD population. The current review reveals how features such as systemic inflammation, hypercoagulation, presence of amyloid fibrin(ogen) in plasma, and marked ultrastructural changes in platelets, probably induced by P. gingivalis, may affect the development of PD. Several other clinical studies have also demonstrated an association between periodontitis and PD. Even if the risk of periodontal diseases causing neurological disorders needs to be better substantiated, that should not keep us from trying to prevent them by performing careful daily dental hygiene.
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页码：2013 / 2018
页数：5
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  • [1] Caton JG(2018)A new classification scheme for periodontal and peri-implant diseases and conditions - introduction and key changes from the 1999 classification J Clin Periodontol 45 S1-S8
  • [2] Armitage G(2005)Defining the normal bacterial flora of the oral cavity J Clin Microbiol 43 5721-5732
  • [3] Berglundh T(2000)Haffajee AD (2005) Periodontal microbial ecology Periodontol 38 135-187
  • [4] Chapple ILC(2018)The oral microbiota: dynamic communities and host interactions Nat Rev Microbiol 16 745-759
  • [5] Jepsen S(2012)The keystone-pathogen hypothesis Nat Rev Microbiol 10 717-725
  • [6] Kornman KS(2012) as a potential community activist for disease J Dent Res 91 816-820
  • [7] Mealey BL(2012)Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology Mol Oral Microbiol 27 409-419
  • [8] Papapanou PN(2014)Community-wide transcriptome of the oral microbiome in subjects with and without periodontitis ISME J 8 1659-1672
  • [9] Sanz M(2018)Dysbiotic biofilms deregulate the periodontal inflammatory response J Dent Res 97 547-555
  • [10] Tonetti MS(1998)Local chemokine paralysis, a novel pathogenic mechanism for Infect Immun 66 1660-1665
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