Comparative genetic architectures of schizophrenia in East Asian and European populations

被引:0
作者
Max Lam
Chia-Yen Chen
Zhiqiang Li
Alicia R. Martin
Julien Bryois
Xixian Ma
Helena Gaspar
Masashi Ikeda
Beben Benyamin
Brielin C. Brown
Ruize Liu
Wei Zhou
Lili Guan
Yoichiro Kamatani
Sung-Wan Kim
Michiaki Kubo
Agung A. A. A. Kusumawardhani
Chih-Min Liu
Hong Ma
Sathish Periyasamy
Atsushi Takahashi
Zhida Xu
Hao Yu
Feng Zhu
Wei J. Chen
Stephen Faraone
Stephen J. Glatt
Lin He
Steven E. Hyman
Hai-Gwo Hwu
Steven A. McCarroll
Benjamin M. Neale
Pamela Sklar
Dieter B. Wildenauer
Xin Yu
Dai Zhang
Bryan J. Mowry
Jimmy Lee
Peter Holmans
Shuhua Xu
Patrick F. Sullivan
Stephan Ripke
Michael C. O’Donovan
Mark J. Daly
Shengying Qin
Pak Sham
Nakao Iwata
Kyung S. Hong
Sibylle G. Schwab
Weihua Yue
机构
[1] Institute of Mental Health Singapore,Bio
[2] Genome Institute of Singapore,X Institutes, Shanghai Jiao Tong University and Research Division
[3] Northwell Health,Human Genetics
[4] Massachusetts General Hospital,Division of Psychiatry Research, the Zucker Hillside Hospital
[5] the Broad Institute of MIT and Harvard,Analytic and Translational Genetics Unit
[6] Institute of Mental Health Singapore,Stanley Center for Psychiatric Research
[7] Harvard Medical School,Research Division
[8] Massachusetts General Hospital,Department of Medicine
[9] Biogen,Psychiatric and Neurodevelopmental Genetics Unit
[10] Qingdao Branch of Shanghai Jiao Tong University Bio-X Institutes and the Affiliated Hospital of Qingdao University,Biomedical Sciences Institute of Qingdao University
[11] Shanghai Jiao Tong University,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Bio
[12] Karolinska Institutet,X Institutes
[13] Chinese Academy of Sciences,Department of Medical Epidemiology and Biostatistics
[14] King’s College London,Key Laboratory of Computational Biology, CAS
[15] Fujita Health University School of Medicine,MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences
[16] University of South Australia Cancer Research Institute,Social Genetic and Developmental Psychiatry
[17] The University of Queensland,Department of Psychiatry
[18] South Australian Health and Medical Research Institute,Australian Centre for Precision Health, School of Health Sciences
[19] Columbia University,Institute for Molecular Bioscience
[20] New York Genome Center,Data Science Institute
[21] Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center
[22] Peking University Sixth Hospital and Institute of Mental Health,Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences
[23] National Health Commission Key Laboratory of Mental Health (Peking University),Laboratory for Statistical Analysis
[24] National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital),Department of Psychiatry
[25] University of Tokyo,Department of Psychiatry, Cipto Mangunkusumo General Hospital
[26] RIKEN Center for Integrative Medical Sciences,Department of Psychiatry
[27] Chonnam National University Medical School,Department of Psychiatry
[28] RIKEN Center for Integrative Medical Sciences,Queensland Center for Mental Health Research
[29] Universitas Indonesia,Department of Genomic Medicine, Research Institute
[30] National Taiwan University Hospital,Department of Psychiatry
[31] National Taiwan University College of Medicine,Center for Translational Medicine
[32] Queensland Brain Institute The University of Queensland,Department of Psychiatry
[33] The University of Queensland,Center for Brain Science
[34] National Cerebral and Cardiovascular Center,Institute of Epidemiology and Preventive Medicine, College of Public Health
[35] University Medical Center Utrecht,Psychiatric Genetic Epidemiology and Neurobiology Laboratory (PsychGENe lab), Department of Psychiatry and Behavioral Sciences
[36] The First Affiliated Hospital of Xi’an Jiaotong University,Baoan Maternal and Child Health Hospital
[37] The First Affiliated Hospital of Xi’an Jiaotong University,Department of Stem Cell and Regenerative Biology
[38] The First Affiliated Hospital of Xi’an Jiaotong University,Department of Genetics
[39] National Taiwan University,Genetics and Genomic Sciences
[40] The State University of New York,MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine
[41] SUNY Upstate Medical University,School of Life Science and Technology
[42] Shanghai Center for Women and Children’s Health,Center for Excellence in Animal Evolution and Genetics
[43] Jinan University,Department of Genetics
[44] Harvard University,Collaborative Innovation Center
[45] Harvard Medical School,State Key Laboratory of Brain and Cognitive Sciences, Centre for Genomic Sciences
[46] Icahn School of Medicine at Mount Sinai,Department of Psychiatry, Li Ka Shing Faculty of Medicine
[47] University of Western Australia,Department of Psychiatry, Sungkyunkwan University School of Medicine
[48] Institute of Mental Health,Molecular Horizons and School of Chemistry and Molecular Bioscience
[49] Cardiff University,Center for Behavioral Genomics, Department of Psychiatry
[50] ShanghaiTech University,Department of Medicine, Yong Loo Lin School of Medicine
来源
Nature Genetics | 2019年 / 51卷
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摘要
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (genetic correlation = 0.98 ± 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of candidate causal variants in 44 loci. Polygenic risk scores had reduced performance when transferred across ancestries, highlighting the importance of including sufficient samples of major ancestral groups to ensure their generalizability across populations.
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页码:1670 / 1678
页数:8
相关论文
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