Multiple sclerosis and pregnancy: What does the patient think? a questionnaire study

被引：14

作者：

Albrecht P. ^{[1
]}

Fischer D. ^{[2
]}

Moser A. ^{[1
]}

机构：

[1] Department of Neurology, University of Lübeck, 23538 Lübeck

[2] Department of Gynaecology and Obstetrics, University of Lübeck, 23538 Lübeck

来源：

BMC Research Notes | / 3卷 / 1期

关键词：

Multiple Sclerosis; Relapse Rate; Correct Answer; Cytokine Profile; Post Partum;

D O I：

10.1186/1756-0500-3-91

中图分类号：

学科分类号：

摘要：

Background. Multiple Sclerosis (MS) is primarily a disease of women in their childbearing years. Pregnancy and puerperium have opposite effects on the course of the disease. Nevertheless, no studies have been carried out yet on the level of information among female MS-patients regarding the interaction between MS and pregnancy. Findings. Demographic data, clinical features of MS, course of MS during pregnancy and puerperium as well as knowledge concerning MS and pregnancy were evaluated by means of a questionnaire in 154 female MS-patients. The level of information was significantly higher (p < 0.001) in women who had been pregnant in the past with the diagnosis MS known at this point of time. Furthermore patients reported about a lower frequency of relapses during pregnancy and a higher frequency of relapses in the first six months after giving birth. Conclusions. The findings illustrate a lack of knowledge in female MS-patients concerning the interactions of MS and pregnancy. In order to make their own independent decision based on scientific facts known to date, female MS-patients need to be better informed on issues regarding MS and pregnancy. © 2010 Albrecht et al; licensee BioMed Central Ltd.

引用

共 17 条

[1]

Weinshenker B.G., Epidemiology of multiple sclerosis, Neurologic Clinics, 14, pp. 291-308, (1996)

[2]

Confavreux C., Vukusic S., Natural history of multiple sclerosis: Implications for counselling and therapy, Current Opinion in Neurology, 15, 3, pp. 257-266, (2002)

[3]

Birk K., Ford C., Smeltzer S., Ryan D., Miller R., Rudick R.A., The clinical course of multiple sclerosis during pregnancy and the puerperium, Archives of Neurology, 47, 7, pp. 738-742, (1990)

[4]

Confavreux C., Hutchinson M., Hours M.M., Cortinovis-Tourniaire P., Moreau T., Rate of pregnancy-related relapse in multiple sclerosis, New England Journal of Medicine, 339, 5, pp. 285-291, (1998)

[5]

Whitaker J.N., Effects of pregnancy and delivery on disease activity in multiple sclerosis, New England Journal of Medicine, 339, 5, pp. 339-340, (1998)

[6]

Worthington J., Jones R., Crawford M., Forti A., Pregnancy and multiple sclerosis a 3-year prospective study, Journal of Neurology, 241, 4, pp. 228-233, (1994)

[7]

Clark D.A., Arck P.C., Chaouat G., Why did your mother reject you? immunogenetic determinants of the response to environmental selective pressure expressed at the uterine level, American Journal of Reproductive Immunology, 41, pp. 55-21, (1999)

[8]

Al-Shammri S., Rawoot P., Azizieh F., AbuQoora A., Hanna M., Saminathan T.R., Raghupathy R., Th1/Th2 cytokine patterns and clinical profiles during and after pregnancy in women with multiple sclerosis, Journal of the Neurological Sciences, 222, 1-2, pp. 21-27, (2004)

[9]

Gilmore W., Arias M., Stroud N., Stek A., McCarthy K.A., Correale J., Preliminary studies of cytokine secretion patterns associated with pregnancy in MS patients, Journal of the Neurological Sciences, 224, 1-2, pp. 69-76, (2004)

[10]

Elenkov I.J., Wilder R.L., Bakalov V.K., Link A.A., Dimitrov M.A., Fisher S., Crane M., Kanik K.S., Chrousos G.P., IL-12, TNF-α, and hormonal changes during late pregnancy and early postpartum: Implications for autoimmune disease activity during these times, Journal of Clinical Endocrinology and Metabolism, 86, 10, pp. 4933-4938, (2001)

← 1 2 →