Malignant Pleural Mesothelioma

被引：0
作者：
Siva Raja
Sudish C. Murthy
David P. Mason
机构：
[1] Cleveland Clinic Foundation,Department of Cardiothoracic Surgery
来源：
Current Oncology Reports | 2011年 / 13卷
关键词：
Mesothelioma; Multimodality therapy; Extrapleural pneumonectomy; Pleurectomy; Malignant pleural mesothelioma; Lung cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Malignant pleural mesothelioma (MPM) is a relatively rare thoracic malignancy accounting for about 2000–3000 new cases per year. This cancer has been increasing in incidence and is strongly associated with asbestos exposure. Also, it is characterized by insidious growth and clinical presentation at an advanced stage of disease. In the past, the treatment of this disease was limited to marginally effective chemotherapy and morbid surgery. This review explores the clinical presentation of MPM, its diagnostic approach and the relevant and recent studies that define the role of chemotherapy, radiation, and various surgical options. Currently, even with aggressive surgical interventions and multimodality strategies, cure remains elusive, although life prolongation has been achieved. Additionally, promising new therapies and interventions that are currently being studied are introduced in this review.
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页码：259 / 264
页数：5
相关论文
共 112 条
[1]  
Yang H(2008)Mesothelioma epidemiology, carcinogenesis, and pathogenesis Curr Treat Options Oncol 9 147-157
[2]  
Testa JR(1976)Thirty-two cases of mesothelioma in Victoria, Australia: a retrospective survey related to occupational asbestos exposure Br J Ind Med 33 115-122
[3]  
Carbone M(1974)Mesothelioma register 1967–68 Br J Ind Med 31 91-104
[4]  
Milne JE(2009)Pathologic evaluation of malignant pleural mesothelioma Semin Thorac Cardiovasc Surg 21 121-124
[5]  
Greenberg M(2010)Translational therapies for malignant pleural mesothelioma Expert Rev Respir Med 4 249-260
[6]  
Davies TA(1989)Diffuse malignant mesothelioma of the pleura in Ontario and Quebec: a retrospective study of 332 patients J Clin Oncol 7 1157-1168
[7]  
Chirieac LR(2009)Prognostic value of 18F-FDG PET/CT in patients with malignant pleural mesothelioma Mol Imag Biol 11 473-479
[8]  
Corson JM(2003)Positron emission tomography defines metastatic disease but not locoregional disease in patients with malignant pleural mesothelioma J Thorac Cardiovasc Surg 126 11-16
[9]  
Belli C(2003)The value of chest computer tomography and cervical mediastinoscopy in the preoperative assessment of patients with malignant pleural mesothelioma Ann Thorac Surg 75 1715-1718
[10]  
Anand S(2005)Integrated computed tomography-positron emission tomography in patients with potentially resectable malignant pleural mesothelioma: staging implications J Thorac Cardiovasc Surg 129 1364-1370
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