Brain-wide visual habituation networks in wild type and fmr1 zebrafish

被引:0
作者
Emmanuel Marquez-Legorreta
Lena Constantin
Marielle Piber
Itia A. Favre-Bulle
Michael A. Taylor
Ann S. Blevins
Jean Giacomotto
Dani S. Bassett
Gilles C. Vanwalleghem
Ethan K. Scott
机构
[1] The University of Queensland,The Queensland Brain Institute
[2] University of Aberdeen,School of Medicine, Medical Sciences, and Nutrition
[3] The University of Queensland,School of Mathematics and Physics
[4] The University of Queensland,Australian Institute for Bioengineering and Nanotechnology
[5] University of Pennsylvania,Department of Bioengineering
[6] West Moreton Hospital and Health Service,Queensland Centre for Mental Health Research
[7] Griffith University,Griffith Institute for Drug Discovery, School of Environment and Science
[8] Griffith University,Discovery Biology
[9] University of Pennsylvania,Departments of Electrical & Systems Engineering, Physics & Astronomy, Neurology, Psychiatry
[10] Santa Fe Institute,Janelia Research Campus
[11] Howard Hughes Medical Institute,Danish Research Institute of Translational Neuroscience – DANDRITE, Nordic
[12] Department of Molecular Biology and Genetics,EMBL Partnership for Molecular Medicine
[13] Aarhus University,undefined
来源
Nature Communications | / 13卷
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摘要
Habituation is a form of learning during which animals stop responding to repetitive stimuli, and deficits in habituation are characteristic of several psychiatric disorders. Due to technical challenges, the brain-wide networks mediating habituation are poorly understood. Here we report brain-wide calcium imaging during larval zebrafish habituation to repeated visual looming stimuli. We show that different functional categories of loom-sensitive neurons are located in characteristic locations throughout the brain, and that both the functional properties of their networks and the resulting behavior can be modulated by stimulus saliency and timing. Using graph theory, we identify a visual circuit that habituates minimally, a moderately habituating midbrain population proposed to mediate the sensorimotor transformation, and downstream circuit elements responsible for higher order representations and the delivery of behavior. Zebrafish larvae carrying a mutation in the fmr1 gene have a systematic shift toward sustained premotor activity in this network, and show slower behavioral habituation.
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