Octreotide end-functionalized diblock copolymers facilitated by RAFT polymerization

被引：0
作者：
Alexander W. Jackson
机构：
[1] Institute of Chemical and Engineering Sciences (ICES),
[2] A* Star Singapore,undefined
来源：
Journal of Polymer Research | 2017年 / 24卷
关键词：
Polymer-peptide conjugate; RAFT polymerization; Grafting-from; End-functionalized;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The incorporation of biologically active targeting ligands into polymeric materials is a key challenge in drug delivery and bioimaging. Reported here is the synthesis of diblock copolymers end-functionalized with the Somatostatin analog Octreotide. This methodology employs a novel Octreotide functional reversible addition-fragmentation chain transfer (RAFT) polymerization chain transfer agent, which is used to mediate the polymerization of N-isopropylacrylamide and subsequent chain-extension with N,N-dimethylacrylamide.
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