Collapsing glomerulopathy in a girl with systemic lupus erythematosus

被引:0
|
作者
M. Fahim Tungekar
Simon Waller
Joanna C. Clothier
机构
[1] St. Thomas’ Hospital,Histopathology Department
[2] Guy’s and St Thomas’ NHS Trust,Paediatric Nephrology Department
[3] Evelina Children’s Hospital,undefined
[4] Guy’s and St Thomas’ NHS Foundation Trust,undefined
来源
Pediatric Nephrology | 2011年 / 26卷
关键词
Collapsing glomerulopathy; Collapsing variant FSGS; Systemic lupus erythematosus; Acute renal failure; Lupus nephritis;
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中图分类号
学科分类号
摘要
Collapsing glomerulopathy has increasingly been recognised in patients with conditions other than HIV. The non-HIV form of collapsing glomerulopathy generally shows little response to standard therapies. We describe a 12-year-old girl with a pre-existing diagnosis of systemic lupus erythematosus presenting with renal failure. A renal biopsy gave the histological diagnosis of collapsing glomerulopathy with evidence of “full-house” immunostaining. We propose collapsing glomerulopathy in her case, as no other cause was found was secondary to systemic lupus erythematosus. The immunophenotype of her podocytes suggested a partial de-differentiation that might have been important in her partial response to immunosuppression.
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页码:809 / 813
页数:4
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