Griseusin D, a New Pyranonaphthoquinone Derivative from a Alkaphilic Nocardiopsis sp.

被引：0
作者：
Yi-Qing Li
Ming-Gang Li
Wei Li
Jiang-Yuan Zhao
Zhang-Gui Ding
Xiao-Long Cui
Meng-Liang Wen
机构：
[1] Laboratory for Conservation and Utilization of Bio-resources,
[2] Key Laboratory of Medicinal Chemistry for Natural Resources,undefined
[3] Ministry of Education,undefined
[4] Yunnan Institute of Microbiology,undefined
[5] Yunnan University,undefined
来源：
The Journal of Antibiotics | 2007年 / 60卷
关键词：
pyranonaphthoquinone; griseusin D; alkaphilic ; sp.;
D O I：
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中图分类号：
学科分类号：
摘要：
A new pyranonaphthoquinone antibiotic, griseusin D (1) was isolated from the cultural fluid of the alkaphilic Nocardiopsis sp. The structure was determined as 5′-one-4-hydroxy-12-methoxygriseusin by spectroscopic methods, comparison with reported data and single-crystal X-ray analysis. 1 displayed strong cytotoxicity against human leukemia cells (HL60) and modest cytotoxicity against human lung adenocarcinoma cell lines (AGZY) with IC50 values of 0.23 and 19.6 μg/ml, respectively. It also exhibited weak antifungal activity against Alternaria alternate with MIC of 140 μg/ml.
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页码：757 / 761
页数：4
相关论文
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