Pit cells as liver-associated natural killer cells: Morphology and function

被引：41

作者：

Nakatani K. ^{[1
]}

Kaneda K. ^{[1
]}

Seki S. ^{[1
]}

Nakajima Y. ^{[2
]}

机构：

[1] Department of Anatomy, Graduate School of Medicine, Osaka City University, Abeno-ku, Osaka 545-8585

[2] Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka

来源：

Medical Electron Microscopy | 2004年 / 37卷 / 1期

关键词：

LGL; Liver; NK cells; NKT cells; Pit cells;

D O I：

10.1007/s00795-003-0229-9

中图分类号：

学科分类号：

摘要：

Pit cells are one type of hepatic sinusoidal cells, defined morphologically as large granular lymphocytes (LGLs) and functionally as liver-associated natural killer (NK) cells. They are situated inside the sinusoidal lumen, adhering to the endothelial cells and Kupffer cells. They contain multivesicular body-related dense granules and rod-cored vesicles. The number and size of granules and vesicles differ between hepatic NK cells and peripheral blood cells, suggesting possible differentiation of the latter into the former in the microenvironment of the liver. In addition to NK cells, natural killer T (NKT) cells are also abundant in the liver. They share several morphological properties with NK cells, and at least some are probably observed as pit cells under an electron microscope. NK cells recognize target cells with their surface receptors such as inhibitory and activating receptors. They exert antitumor functions by exocytosis of perforin/granzyme-containing granules, induction of death receptor-mediated apoptosis in target cells, and production of various cytokines that augment the activities of other immune cells. NKT cells play important roles in initiating and assisting the function of NK cells by producing interferon-gamma.

引用

页码：29 / 36

页数：7

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