Radiation Exposure and Mortality from Cardiovascular Disease and Cancer in Early NASA Astronauts

被引:44
作者
Elgart, S. Robin [1 ]
Little, Mark P. [2 ]
Chappell, Lori J. [3 ]
Milder, Caitlin M. [4 ]
Shavers, Mark R. [3 ]
Huff, Janice L. [5 ]
Patel, Zarana S. [3 ]
机构
[1] Univ Houston, Houston, TX USA
[2] NCI, Radiat Epidemiol Branch, DHHS, NIH,Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
[3] KBRwyle, Sci & Space Operat, Houston, TX 77058 USA
[4] NASA, Lyndon B Johnson Space Ctr, Houston, TX 77058 USA
[5] MEI Technol, Houston, TX USA
基金
美国国家卫生研究院;
关键词
DEEP SPACE RADIATION; IONIZING-RADIATION; CIRCULATORY DISEASE; UNITED-KINGDOM; RISK; CHILDHOOD; LEUKEMIA; WORKERS; FRANCE; HEALTH;
D O I
10.1038/s41598-018-25467-9
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Understanding space radiation health effects is critical due to potential increased morbidity and mortality following spaceflight. We evaluated whether there is evidence for excess cardiovascular disease or cancer mortality in early NASA astronauts and if a correlation exists between space radiation exposure and mortality. Astronauts selected from 1959-1969 were included and followed until death or February 2017, with 39 of 73 individuals still alive at that time. Calculated standardized mortality rates for tested outcomes were significantly below U.S. white male population rates, including all-cardiovascular disease (n = 7, SMR = 33; 95% CI, 14-65) and all-cancer (n = 7, SMR = 43; 95% CI, 18-83), as anticipated in a healthy worker population. Space radiation doses for cohort members ranged from 0-78 mGy. No significant associations between space radiation dose and mortality were found using logistic regression with an internal reference group, adjusting for medical radiation. Statistical power of the logistic regression was < 6%, remaining < 12% even when expected risk level or observed deaths were assumed to be 10 times higher than currently reported. While no excess radiation-associated cardiovascular or cancer mortality risk was observed, findings must be tempered by the statistical limitations of this cohort; notwithstanding, this small unique cohort provides a foundation for assessment of astronaut health.
引用
收藏
页数:9
相关论文
共 54 条
[1]   Do Apollo Astronaut Deaths Shine a Light on Deep Space Radiation and Cardiovascular Disease? [J].
Abbasi, Jennifer .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 316 (23) :2469-2470
[2]   Incidence Rate of Cardiovascular Disease End Points in the National Aeronautics and Space Administration Astronaut Corps [J].
Ade, Carl J. ;
Broxterman, Ryan M. ;
Charvat, Jacqueline M. ;
Barstow, Thomas J. .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (08)
[3]  
[Anonymous], 2000, EPIDEMIOLOGY
[4]  
[Anonymous], 2013, SPACE RAD CANC RISK
[5]  
[Anonymous], SAFE PASSAGE ASTRONA
[6]  
[Anonymous], TERRESTRIAL SPACE RA
[7]  
[Anonymous], EFF ION RAD UN SCI C
[8]  
[Anonymous], ASTRONAUT EXPOSURE S
[9]  
[Anonymous], TRANSPORT METHODS IN
[10]  
[Anonymous], WORKING GROUP RAD PR