Pharmacokinetics of alemtuzumab in pediatric patients undergoing ex vivo T-cell-depleted haploidentical hematopoietic cell transplantation

被引:0
作者
Senthil Velan Bhoopalan
Shane J. Cross
John C. Panetta
Brandon M. Triplett
机构
[1] St. Jude Children’s Research Hospital,Department of Hematology
[2] St. Jude Children’s Research Hospital,Department of Pharmaceutical Sciences
[3] St. Jude Children’s Research Hospital,Department of Bone Marrow Transplantation and Cell Therapy
来源
Cancer Chemotherapy and Pharmacology | 2020年 / 86卷
关键词
Alemtuzumab; Pharmacokinetics; Haploidentical bone marrow transplantation; T-cell-depleted transplantation; Pediatric bone marrow transplantation; Campath; Bone marrow; Peripheral blood stem cell;
D O I
暂无
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学科分类号
摘要
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页码:711 / 717
页数:6
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共 182 条
[1]  
Alexander TB(2017)Decreased relapsed rate and treatment-related mortality contribute to improved outcomes for pediatric acute myeloid leukemia in successive clinical trials Cancer 123 3791-3798
[2]  
Wang L(2017)Minimal residual disease-guided therapy in childhood acute lymphoblastic leukemia Blood 129 1913-1918
[3]  
Inaba H(2018)Have haploidentical transplants replaced umbilical cord transplants for acute leukemias? Curr Opin Hematol 25 103-111
[4]  
Triplett BM(2017)T-cell manipulation strategies to prevent graft-versus-host disease in haploidentical stem cell transplantation Biomedicines 123 967-973
[5]  
Pounds S(2014)"Designed" grafts for HLA-haploidentical stem cell transplantation Blood 144 818-831
[6]  
Ribeiro RC(2009)Rediscovering alemtuzumab: current and emerging therapeutic roles Br J Haematol 96 2419-2425
[7]  
Pui CH(2000)In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation Blood 49 55-61
[8]  
Rubnitz JE(2014)The impact of T-cell depletion techniques on the outcome after haploidentical hematopoietic SCT Bone Marrow Transplant 64 278-291
[9]  
Campana D(2007)Population pharmacokinetics-pharmacodynamics of alemtuzumab (Campath) in patients with chronic lymphocytic leukaemia and its link to treatment response Br J Clin Pharmacol 58 1609-1620
[10]  
Pui C-H(2019)Population pharmacokinetics of alemtuzumab (campath) in pediatric hematopoietic cell transplantation: towards individualized dosing to improve outcome Clin Pharmacokinet 10 2769-504