Centromere DNA, proteins and kinetochore assembly in vertebrate cells

被引：0
作者：
Tatsuo Fukagawa
机构：
[1] National Institute of Genetics and The Graduate University for Advanced Studies,PRESTO, the Japan Science and Technology Agency (JST)
来源：
Chromosome Research | 2004年 / 12卷
关键词：
CENP; centromere; DT40; kinetochore; mitosis; repeat DNA;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The centromere is a specialized region of the chromosome that is essential for faithful chromosome segregation during mitosis and meiosis in eukaryotic cells. It is the site at which the kinetochore, the functional nucleoprotein complex responsible for microtubule binding and chromosome movement, is assembled through complex molecular mechanisms. Herein, I review recent advances in our understanding of centromeric DNAs as sites for kinetochore assembly and the mechanisms underlying kinetochore assembly in vertebrate cells.
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页码：557 / 567
页数：10
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