Age-related changes in P wave morphology in healthy subjects

被引：45
作者：
Havmoller R. [1 ]
Carlson J. [1 ]
Holmqvist F. [1 ]
Herreros A. [2 ]
Meurling C.J. [1 ]
Olsson B. [1 ]
Platonov P. [1 ]
机构：
[1] Department of Cardiology, Lund University Hospital, Lund
[2] Department of Automatic Control, Valladolid University, Valladolid
来源：
BMC Cardiovascular Disorders | / 7卷 / 1期
关键词：
Atrial Fibrillation; Paroxysmal Atrial Fibrillation; Right Atrium; Intraindividual Variation; Wave Morphology;
D O I：
10.1186/1471-2261-7-22
中图分类号：
学科分类号：
摘要：
Background: We have previously documented significant differences in orthogonal P wave morphology between patients with and without paroxysmal atrial fibrillation (PAF). However, there exists little data concerning normal P wave morphology. This study was aimed at exploring orthogonal P wave morphology and its variations in healthy subjects. Methods: 120 healthy volunteers were included, evenly distributed in decades from 20-80 years of age; 60 men (age 50+/-17) and 60 women (50+/-16). Six-minute long 12-lead ECG registrations were acquired and transformed into orthogonal leads. Using a previously described P wave triggered P wave signal averaging method we were able to compare similarities and differences in P wave morphologies. Results: Orthogonal P wave morphology in healthy individuals was predominately positive in Leads X and Y. In Lead Z, one third had negative morphology and two-thirds a biphasic one with a transition from negative to positive. The latter P wave morphology type was significantly more common after the age of 50 (P < 0.01). P wave duration (PWD) increased with age being slightly longer in subjects older than 50 (121+/-13 ms vs. 128+/-12 ms, P < 0.005). Minimal intraindividual variation of P wave morphology was observed. Conclusion: Changes of signal averaged orthogonal P wave morphology (biphasic signal in Lead Z), earlier reported in PAF patients, are common in healthy subjects and appear predominantly after the age of 50. Subtle age-related prolongation of PWD is unlikely to be sufficient as a sole explanation of this finding that is thought to represent interatrial conduction disturbances. To serve as future reference, P wave morphology parameters of the healthy subjects are provided. © 2007 Havmoller et al; licensee BioMed Central Ltd.
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