Synthesis and antimicrobial activity of novel derivatives of Biginelli pyrimidines

被引：0
作者：
Bita Sedaghati
Afshin Fassihi
Shirin Arbabi
Mahnaz Ranjbar
Hamid Reza Memarian
Lotfollah Saghaie
Adel Omidi
Alireza Sardari
Mohammad Jalali
Daryoush Abedi
机构：
[1] Isfahan University of Medical Sciences,Department of Medicinal Chemistry and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences
[2] University of Isfahan,Department of Chemistry, Faculty of Sciences
[3] Isfahan University of Medical Sciences,School of Health
[4] Isfahan University of Medical Sciences,Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
Antibacterial activity; Antifungal activity; 1,2,3,4-Tetrahydropyrimidine-5-carboxamides; 1,2,3,4-Tetrahydropyrimidine-5-carboxylate esters;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of novel Biginelli pyrimidines was prepared and evaluated for antimicrobial activity. Weak inhibitory activity (MIC = 128 μg/ml) was observed from 3b and 8b, against S. aureus and P. aeruginosa, respectively. Moderate antifungal agents: 4c, 4d, 4e with MIC = 32 μg/ml, 3d, 7b, and 8b with MIC = 64 μg/ml against C.albicans were determined. 4c, 4d, 4e, and 7b proved to be moderate antifungals against A. niger with MIC = 64 μg/ml.
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页码：3973 / 3983
页数：10
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