Combining Biology and Chemistry for a New Take on Chemotherapy: Antibody-Drug Conjugates in Hematologic Malignancies

[1] Kohler G(1975)Continuous cultures of fused cells secreting antibody of predefined specificity Nature 256 495-497

[2] Milstein C(1984)The 1984 Nobel Prize in medicine Science 226 1025-1028

[3] Uhr JW(1987)Chimeric mouse-human IgG1 antibody that can mediate lysis of cancer cells Proc Natl Acad Sci U S A 84 3439-3443

[4] Liu AY(1997)IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin’s lymphoma Blood 90 2188-2195

[5] Maloney DG(2000)Multicenter phase II study of iodine-131 tositumomab for chemotherapy-relapsed/refractory low-grade and transformed low-grade B-cell non-Hodgkin’s lymphomas J Clin Oncol 18 1316-1323

[6] Vose JM(1999)Phase I/II trial of IDEC-Y2B8 radioimmunotherapy for treatment of relapsed or refractory CD20(+) B-cell non-Hodgkin’s lymphoma J Clin Oncol 17 3793-3803

[7] Witzig TE(2006)Antibody targeted drugs as cancer therapeutics Nat Rev Drug Discov 5 147-159

[8] Schrama D(1999)Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate Blood 93 3678-3684

[9] Reisfeld RA(1987)Calichemicins, a novel family of antitumor antibiotics. 1. Chemistry and partial structure of calichemicin.gamma.1I J Am Chem Soc 109 3464-3466

[10] Becker JC(1989)Calicheamicins, a novel family of antitumor antibiotics. 3. Isolation, purification and characterization of calicheamicins beta 1Br, gamma 1Br, alpha 2I, alpha 3I, beta 1I, gamma 1I and delta 1I J Antibiot (Tokyo) 42 1070-1087

[1] Kohler G(1975)Continuous cultures of fused cells secreting antibody of predefined specificity Nature 256 495-497

[2] Milstein C(1984)The 1984 Nobel Prize in medicine Science 226 1025-1028

[3] Uhr JW(1987)Chimeric mouse-human IgG1 antibody that can mediate lysis of cancer cells Proc Natl Acad Sci U S A 84 3439-3443

[4] Liu AY(1997)IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin’s lymphoma Blood 90 2188-2195

[5] Maloney DG(2000)Multicenter phase II study of iodine-131 tositumomab for chemotherapy-relapsed/refractory low-grade and transformed low-grade B-cell non-Hodgkin’s lymphomas J Clin Oncol 18 1316-1323

[6] Vose JM(1999)Phase I/II trial of IDEC-Y2B8 radioimmunotherapy for treatment of relapsed or refractory CD20(+) B-cell non-Hodgkin’s lymphoma J Clin Oncol 17 3793-3803

[7] Witzig TE(2006)Antibody targeted drugs as cancer therapeutics Nat Rev Drug Discov 5 147-159

[8] Schrama D(1999)Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate Blood 93 3678-3684

[9] Reisfeld RA(1987)Calichemicins, a novel family of antitumor antibiotics. 1. Chemistry and partial structure of calichemicin.gamma.1I J Am Chem Soc 109 3464-3466

[10] Becker JC(1989)Calicheamicins, a novel family of antitumor antibiotics. 3. Isolation, purification and characterization of calicheamicins beta 1Br, gamma 1Br, alpha 2I, alpha 3I, beta 1I, gamma 1I and delta 1I J Antibiot (Tokyo) 42 1070-1087