Postural variation in intraocular pressure in primary chronic autonomic failure

被引：0

作者：

Martin J. Dumskyj

Christopher J. Mathias

Caroline J. Doré

Katharine Bleasdale-Barr

Eva M. Kohner

机构：

[1] Neurovascular Medicine Unit,

[2] Division of Neuroscience and Psychological Medicine,undefined

[3] Imperial College of Science,undefined

[4] Technology and Medicine at St. Mary's,undefined

[5] Praed Street,undefined

[6] London,undefined

[7] UK,undefined

[8] W2 1NY and Autonomic Unit,undefined

[9] National Hospital for Neurology and Neurosurgery,undefined

[10] and University Department of Clinical Neurology,undefined

[11] Institute of Neurology,undefined

[12] University College London,undefined

[13] Queen Square London,undefined

[14] UK,undefined

[15] WC1N 3BG,undefined

[16] Department of Oncology,undefined

[17] Gastroenterology,undefined

[18] Endocrinology and Metabolism,undefined

[19] St. George's Hospital Medical School,undefined

[20] Cranmer Terrace,undefined

[21] London,undefined

[22] UK,undefined

[23] SW17 ORE,undefined

[24] Medical Statistics Unit,undefined

[25] Imperial College of Science,undefined

[26] Technology and Medicine,undefined

[27] Hammersmith Campus,undefined

[28] Du Cane Road,undefined

[29] London,undefined

[30] UK W12 0NN,undefined

[31] Department of Medicine,undefined

[32] St. Thomas' Hospital,undefined

[33] Lambeth Palace Road,undefined

[34] London,undefined

[35] UK,undefined

[36] SE1 7EH,undefined

来源：

Journal of Neurology | 2002年 / 249卷

关键词：

Key words intraocular pressure; posture; autonomic failure; systemic blood pressure; mean arterial pressure.;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Patients with syndromes of generalised autonomic failure often have extreme posture-related lability of blood pressure, with both orthostatic hypotension and recumbent hypertension. Whether these changes influence intraocular pressure (IOP) is not known. Mean arterial pressure (MAP) and IOP were measured in response to variations in posture between +45° and −20° in 8 normal subjects and 9 subjects with primary generalised chronic autonomic failure (AF). With postural change normal subjects showed minimal change in MAP (p=0.6) and small but significant changes in IOP (p < 0.001). Subjects with AF showed large and significant changes in both MAP (p < 0.001) and IOP (p < 0.001). Two AF subjects had raised IOP when recumbent, despite normal IOP at +45°. There was significant covariance of MAP and IOP (p < 0.001 overall, p=0.004 in normal subjects, p=0.006 in AF subjects). However, individually, those patients with large changes in IOP could not be predicted from changes in MAP. These data show that patients with autonomic failure are subject to large posture-related changes in IOP. These appear to be related to the large posture-induced changes in systemic blood pressure which occur in these patients.

引用

页码：712 / 718

页数：6