Cortical spreading depression: Its role in migraine pathogenesis and possible therapeutic intervention strategies

被引：18
作者：
Parsons A.A. [1 ]
机构：
[1] Department of Neurology, GI Ctr. of Excellence Drug Discovery, GlaxoSmithKline, Harlow, Essex CM19 5AW, New Frontiers Science Park
来源：
Current Pain and Headache Reports | 2004年 / 8卷 / 5期
关键词：
Migraine; Sumatriptan; Migraine With Aura; Cortical Spreading Depression; Spreading Depression;
D O I：
10.1007/s11916-996-0016-0
中图分类号：
学科分类号：
摘要：
Cortical spreading depression (CSD) is a well-characterized phenomenon in experimental animals. Recent data show that CSD actually can occur in the injured human brain and compelling evidence is accumulating to support the concept that CSD is responsible for migraine aura. The aim of this review is to highlight recent key advances regarding our understanding of CSD in animal and human studies and its relevance to the pathophysiology of migraine and its potential treatment options. Copyright © 2004 by Current Science Inc.
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收藏
页码：410 / 416
页数：6
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