Synthesis of novel biologically active methylene derivatives of sydnones

被引：0
作者：
Shahrukh T. Asundaria
Christophe Pannecouque
Erik De Clercq
Claudiu T. Supuran
Keshav C. Patel
机构：
[1] Veer Narmad South Gujarat University,Department of Chemistry
[2] Rega Institute for Medical Research,Department of Microbiology and Immunology
[3] KU Leuven,Dipartimento di Scienze Farmaceutiche
[4] University of Florence,undefined
来源：
Medicinal Chemistry Research | 2013年 / 22卷
关键词：
Mannich base; Sydnone; Antiviral; Anticancer; Antibacterial; Antifungal;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of mono and bis N-Mannich bases incorporating 3-(4-methylphenyl)-4-(substituted-1/4-ylmethyl)sydnone scaffolds were synthesized and tested for their antibacterial, antifungal, anticancer, and antiviral activities. Most of the compounds showed moderate-to-significant antibacterial and antifungal activities. The compounds did not show selective activity against HIV. Some of the compounds have been evaluated for anticancer activity, but they were found as poorly active. The structures of the synthesized compounds were elucidated by IR and NMR spectroscopy.
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页码：5752 / 5763
页数：11
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