Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: A case report

被引：12

作者：

El Ammari J.E. ^{[1
]}

Ahsaini M. ^{[1
]}

Riyach O. ^{[1
]}

El Fassi M.J. ^{[1
]}

Farih M.H. ^{[1
]}

Hammas N. ^{[2
]}

Elfatmi H. ^{[2
]}

Amarti A. ^{[2
]}

机构：

[1] Department of Urology, University Hospital Center Hassan II, Fez 30000, Route Sidi Hrazem

[2] Department of Pathology, Hospital University Center Hassan II, Fez 30000, Route Sidi Hrazem

来源：

Journal of Medical Case Reports | / 7卷 / 1期

关键词：

Adenocarcinoma; Chemotherapy; Primary signet-ring cell carcinoma; Urinary bladder;

D O I：

10.1186/1752-1947-7-37

中图分类号：

学科分类号：

摘要：

Introduction. Primary signet-ring cell carcinoma of the urinary bladder is a rare variant of mucus-producing adenocarcinoma constituting approximately 0.5% to 2.0% of all primary carcinomas of the bladder. This tumor initially presents as a high-grade, high-stage lesion and diffusely invades the bladder wall without forming intraluminal growth. The patients have no specific symptoms, which leads to delayed diagnosis and poor prognosis. Case presentation. We report the case of a 51-year-old Moroccan Berber man consulting for gross hematuria. Ultrasonography and a computed tomography scan found a bladder tumor diffusely invading the bladder wall. A histopathological examination of the tumor chips from a transurethral resection of the bladder revealed signet-ring cell adenocarcinoma. The gastrointestinal tract exploration did not reveal any other tumor localization. A radical cystectomy and adjuvant cisplatin and gemcitabine chemotherapy were therefore performed resulting in 18 months of survival without metastasis and a good quality of life within that time. Conclusion: The rarity and the successful management with carboplatin and gemcitabine as adjuvant chemotherapy of this entity, which is rarely reported in the literature, are two remarkable characteristics described in this case report. © 2013 El Ammari et al.; licensee BioMed Central Ltd.

引用

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