Evolutionary features of influenza A/H5N1 virus populations in Egypt: poultry and human health implications

被引：0
作者：
Mahmoud M. Naguib
E. M. Abdelwhab
Timm C. Harder
机构：
[1] Friedrich-Loeffler-Institut,The Federal Research Institute for Animal Health
[2] Institute of Diagnostic Virology,National Laboratory for Veterinary Quality Control on Poultry Production
[3] Animal Health Research Institute,undefined
来源：
Archives of Virology | 2016年 / 161卷
关键词：
H5N1 Virus; High Posterior Density; H5N1 Infection; High Posterior Density; Highly Pathogenic Avian Influenza Virus;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Since 2006, in Egypt, highly pathogenic avian influenza virus (HPAIV) H5N1 has established endemic status in poultry. Bayesian evolutionary analysis sampling trees suggested an introduction date in the third quarter of 2005. Evolutionary dynamics using Bayesian analysis showed that H5N1 viruses of clade 2.2.1.1 evolved at higher rates than those of clade 2.2.1.2. Bayesian skyline plot analysis of the HA gene of 840 and NA gene of 401 Egyptian H5N1 viruses from 2006-2015 identified two waves of viral population expansion correlating with the stepwise emergence of the 2.2.1.1 variant lineage in 2008 and with the newly emerging 2.2.1.2 cluster in late 2014. H5N1 infections in human hosts in 2014-2015 were statistically linked to a contemporary poultry outbreak.
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页码：1963 / 1967
页数：4
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