Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus

被引:0
作者
Yao-Chung Chuang
Tsu-Kung Lin
Hsuan-Ying Huang
Wen-Neng Chang
Chia-Wei Liou
Shang-Der Chen
Alice YW Chang
Samuel HH Chan
机构
[1] Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine,Department of Neurology
[2] Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine,Center for Translational Research in Biomedical Sciences
[3] Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine,Department of Pathology
来源
Journal of Neuroinflammation | / 9卷
关键词
Status epilepticus; Mitochondrial uncoupling protein 2; Peroxisome proliferator-activated receptors γ; Hippocampal neuronal cell death; Oxidative stress;
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[1]  
Henshall DC(2005)Epilepsy and apoptosis pathways J Cereb Blood Flow Metab 25 1557-1572
[2]  
Simon RP(2010)The potential role of mitochondrial dysfunction in seizure-associated cell death in the hippocampus and epileptogenesis J Bioenerg Biomembr 42 461-465
[3]  
Chen SD(2005)Progressive hippocampal and extrahippocampal atrophy in drug resistant epilepsy Curr Opin Neurol 18 173-177
[4]  
Chang AYW(2000)Magnetic resonance imaging follow-up of progressive hippocampal changes in a mouse model of mesial temporal lobe epilepsy Epilepsia 41 642-650
[5]  
Chuang YC(2004)Mitochondrial dysfunction and ultrastructural damage in the hippocampus during kainic acid-induced status epilepticus in the rat Epilepsia 45 1202-1209
[6]  
Cendes F(2002)Mitochondrial dysfunction associated with neuronal death following status epilepticus in rat Epilepsy Res 48 157-168
[7]  
Bouilleret V(2010)Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid Neurochem Int 56 394-403
[8]  
Nehlig A(2002)Seizure-dependent modulation of mitochondrial oxidative phosphorylation in rat hippocampus Eur J Neurosci 15 1105-1114
[9]  
Marescaux C(2000)Mitochondrial complex I deficiency in the epileptic focus of patients with temporal lobe epilepsy Ann Neurol 48 766-773
[10]  
Namer IJ(2009)Mitochondrial involvement in temporal lobe epilepsy Exp Neurol 218 326-332