Design, Synthesis, and Characterization of Novel Benzimidazole Derivatives and Their Biological Assessment

被引：0

作者：

Sunitha, Ch. ^{[1
]}

Brahmeshwari, G. ^{[1
]}

机构：

[1] Kakatiya Univ, Dept Chem, Warangal 506009, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 01期

关键词：

benzimidazole; thiadiazole; oxadiazole; triazole; antibacterial activity; antioxidant activity;

D O I：

10.1134/S1070428024010202

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new benzimidazole derivatives containing 1,3,4-thiadiazole, 1,3,4-oxadiazole, thiazolidine, or 1,2,4-triazole ring have been synthesized. All newly synthesized compounds were characterized by IR, H-1 and C-13 NMR, and LC/MS spectroscopy and were tested for their antibacterial and antioxidant activities. Among the synthesized compounds, 2-{2-[2-(cyanomethyl)-1H-benzimidazol-1-yl]acetyl}-N-phenylhydrazinecarboxamideshowed the best antioxidant activity, and N '-(4-bromobenzylidene)-2-[2-(cyanomethyl)-1H-benzimidazol-1-yl]acetohydrazide exhibited the lowest minimum inhibitory concentration against Enterobacter aerogenes.

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页码：155 / 163

页数：9

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