Design, Synthesis, and Characterization of Novel Benzimidazole Derivatives and Their Biological Assessment

被引:0
作者
Sunitha, Ch. [1 ]
Brahmeshwari, G. [1 ]
机构
[1] Kakatiya Univ, Dept Chem, Warangal 506009, India
关键词
benzimidazole; thiadiazole; oxadiazole; triazole; antibacterial activity; antioxidant activity;
D O I
10.1134/S1070428024010202
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A series of new benzimidazole derivatives containing 1,3,4-thiadiazole, 1,3,4-oxadiazole, thiazolidine, or 1,2,4-triazole ring have been synthesized. All newly synthesized compounds were characterized by IR, H-1 and C-13 NMR, and LC/MS spectroscopy and were tested for their antibacterial and antioxidant activities. Among the synthesized compounds, 2-{2-[2-(cyanomethyl)-1H-benzimidazol-1-yl]acetyl}-N-phenylhydrazinecarboxamideshowed the best antioxidant activity, and N '-(4-bromobenzylidene)-2-[2-(cyanomethyl)-1H-benzimidazol-1-yl]acetohydrazide exhibited the lowest minimum inhibitory concentration against Enterobacter aerogenes.
引用
收藏
页码:155 / 163
页数:9
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