Isokinetic correlation analysis of the series of electrophilic substitution reactions ofo-substituted phenylmercurials

Isokinetic relationships of the series of electrophilic substitution reactions ofo-substituted phenylmercurials are studied, and the results show, for the first time, that isokinetic correlation analysis can reveal the dominant factor in the system of the reactions. The analysis of SE2 ofo-substituted phenylmercuric chlorides indicates that the steric effect ofo-substituents is the predominant factor when I2 is used as electrophilic agent, however, the electronic effect ofo-substituents would become the predominant factor when HCl is used as the electrophilic agent. In SE1 ofo-substituted phenylmercuric chlorides, the results of the analysis display that the predominant factor is the field effects ofo-substituents. The determination of predominant factors in those reactions would provide further scientific basis for those reaction mechanisms.