Deoxypodophyllotoxin induces cytoprotective autophagy against apoptosis via inhibition of PI3K/AKT/mTOR pathway in osteosarcoma U2OS cells

被引:1
作者
Sang-Hun Kim
Kyo-Min Son
Kwang-Youn Kim
Sun-Nyoung Yu
Sul-Gi Park
Young-Wook Kim
Hyo-Won Nam
Jeung-Tak Suh
Jae-Hoon Ji
Soon-Cheol Ahn
机构
[1] Pusan National University School of Medicine,Department of Microbiology & Immunology
[2] Hana Hospital,Department of Orthopedic Surgery
[3] Daegu Haany University,Department of Herbal Formula, Medical Research Center (MRC
[4] Pusan National University School of Medicine,GHF), College of Oriental Medicine
[5] Ajou University School of Medicine,Department of Orthopedic Surgery
[6] Pusan National University,Genome Instability Research Center
来源
Pharmacological Reports | 2017年 / 69卷
关键词
Deoxypodophyllotoxin; DPT; Reactive oxygen species; ROS; Apoptosis;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:878 / 884
页数:6
相关论文
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[1]  
Durfee RA(2016)Review of osteosarcoma and current management Rheumatol Ther 3 221-43
[2]  
Mohammed M(2005)Bisphosphonates for treatment and prevention of bone metastases J Clin Oncol 23 8219-24
[3]  
Luu HH(2011)Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents Eur J Med Chem 46 4056-61
[4]  
Michaelson MD(2015)Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in SGC-7901 cells and inhibits tumor growth in vivo Molecules 20 1661-75
[5]  
Smith MR(2009)Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: induction of G2/M cell cycle arrest and caspase-dependent apoptosis Bioorg Med Chem Lett 19 4367-71
[6]  
Jin Y(2010)Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells Cancer Lett 287 231-9
[7]  
Liu J(2000)Apoptosis in cancer Carcinogenesis 21 485-95
[8]  
Huang WT(2015)Cellular and metabolic functions for autophagy in cancer cells Trends Cell Biol 25 37-45
[9]  
Chen SW(2014)Cell cycle regulation by the nutrient-sensing mammalian target of rapamycin (mTOR) pathway Methods Mol Biol 1170 113-44
[10]  
Hui L(2010)The origin of the autophagosomal membrane Nat Cell Biol 12 831-5