Copper-mediated oxidative stress in rat liver

被引：6
作者：
Dervis Ozcelik
Resat Ozaras
Zafer Gurel
Hafize Uzun
Seval Aydin
机构：
[1] University of Istanbul,Department of Biophysics
[2] University of Istanbul,Department of Infectious Diseases and Clinical Microbilogy
[3] University of Istanbul,Department of Biochemistry, Cerrahpasa Medical Faculty
来源：
Biological Trace Element Research | 2003年 / 96卷
关键词：
Copper; lipid peroxidation; superoxide dismutase; malondialdehyde; glutathione;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Copper is an essential trace element with various biological functions. Excess copper, however, is extremely toxic, leading to many pathological conditions that are consistent with oxidative damage to membranes and molecules. Exposure to high levels of copper results in various changes in the tissues. In liver, hypertrophy of hepatocytes, hepatitis, hepatocellular necrosis, and hepatocellular death are the results. Lipid peroxidation causes dysfunction in the cell membrane, decreased fluidity, inactivation of receptors and enzymes, and changes ion permeability. In this study, we aimed to determine the effect of copper on oxidative and antioxidative substances in plasma and liver tissue in a rat model.
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页码：209 / 215
页数：6
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