Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: A case report

被引：15

作者：

Nakajima A. ^{[1
]}

Takahashi H. ^{[1
]}

Inamori M. ^{[1
]}

Abe Y. ^{[1
]}

Kobayashi N. ^{[1
]}

Kubota K. ^{[1
]}

Yamanaka S. ^{[2
]}

机构：

[1] Gastroenterology Division, Yokohama City University Hospital, Kanazawa-ku, Yokohama 236-0004

[2] Division of Pathology, Yokohama City University Hospital, Kanazawa-ku, Yokohama 236-0004

来源：

Journal of Medical Case Reports | / 2卷 / 1期

关键词：

Pancreatic Cancer; Pancreatic Carcinoma; Interstitial Pneumonia; Large Cell Carcinoma; Anaplastic Carcinoma;

D O I：

10.1186/1752-1947-2-391

中图分类号：

学科分类号：

摘要：

Introduction: The granulocyte-colony stimulating factor-producing tumor was first reported in 1977, however, anaplastic pleomorphic type carcinoma of the pancreas producing granulocyte-colony stimulating factor is still rare. Case presentation: A 63-year-old man was admitted to our hospital with body weight loss (-10 kg during months) and upper abdominal pain from 3 weeks. Abdominal computed tomography demonstrated a pancreatic tumor 10 cm in size and multiple low-density areas in the liver. On admission, the peripheral leukocyte count was elevated to 91,500/mm3 and the serum concentration of granulocyte-colony stimulating factor was 134 pg/mL (normal, < 18.1 pg/mL). Based on liver biopsy findings, the tumor was classified as an anaplastic pleomorphic-type carcinoma. Immunohistochemical staining showed that pancreatic carcinoma cells were positive for granulocyte-colony stimulating factor. The patient developed interstitial pneumonia, probably caused by granulocyte-colony stimulating factor, and died 11 days after admission. Conclusion: This is a rare case report of anaplastic pleomorphic-type carcinoma of the pancreas producing granulocyte-colony stimulating factor and confirmed by immunohistochemistry. © 2008 Nakajima et al; licensee BioMed Central Ltd.

引用

共 13 条

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