Brief report: Glutamate transporter gene (SLC1A1) single nucleotide polymorphism (rs301430) and repetitive behaviors and anxiety in children with autism spectrum disorder

被引：0

作者：

Gadow K.D. ^{[1
,5
]}

Roohi J. ^{[2
]}

Devincent C.J. ^{[3
]}

Kirsch S. ^{[4
]}

Hatchwell E. ^{[4
]}

机构：

[1] Department of Psychiatry, Stony Brook University, New York, NY

[2] Department of Genetics, Stony Brook University, Stony Brook, NY

[3] Department of Pediatrics, Stony Brook University, Stony Brook, NY

[4] Department of Pathology, Stony Brook University, Stony Brook, NY

[5] Department of Psychiatry, Stony Brook University, Putnam Hall, Stony Brook

来源：

Journal of Autism and Developmental Disorders | 2010年 / 40卷 / 9期

基金：

美国国家卫生研究院;

关键词：

Autism; Autism spectrum disorder; Generalized anxiety; Obsessive-compulsive behaviors; Separation anxiety; SLC1A1;

D O I：

10.1007/s10803-010-0961-7

中图分类号：

学科分类号：

摘要：

Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive-compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples. © 2010 Springer Science+Business Media, LLC.

引用

页码：1139 / 1145

页数：6

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