History of Changes in the Protocol of Clinical Trial of Zinc Supplementation in Treatment of COVID-19 by Hydroxychloroquine

被引：0

作者：

Dorn Sornsil

Kouji H. Harada

Arthit Phosri

机构：

[1] Kyoto University Graduate School of Medicine,Department of Social Epidemiology

[2] Kyoto University Graduate School of Medicine,Department of Health Environmental Sciences

[3] Mahidol University,Department of Environmental Health Sciences, Faculty of Public Health

来源：

Biological Trace Element Research | 2024年 / 202卷

关键词：

Zinc supplement; Hydroxychloroquine; COVID-19; Clinical trial; Registration; Protocol;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An article published in this journal used a randomized controlled trial to evaluate the efficacy of combining chloroquine/hydroxychloroquine (CQ/HCQ) and zinc in the treatment of COVID-19 patients. Findings from this study indicate that zinc supplements did not enhance the clinical efficacy of hydroxychloroquine in improving COVID-19 treatment. Although this finding is consistent with many previous studies, several concerns regarding study protocol and trial registration, including interventions and primary outcomes, have been raised in which the protocol has been changed after the completion of the recruitment.

引用

页码：1926 / 1927

页数：1

共 12 条

[1]

Abd-Elsalam S(2021)Do zinc supplements enhance the clinical efficacy of hydroxychloroquine?: a randomized, multicenter trial Biol Trace Elem Res 199 3642-3646

[2]

Soliman S(2021)Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection: the COVID A to Z randomized clinical trial JAMA Netw Open 4 e210369-2040

[3]

Esmail ES(2020)Effect of hydroxychloroquine in hospitalized patients with Covid-19 N Engl J Med 383 2030-958

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Thomas S(2005)Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1) BMJ 330 956-undefined

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