Interferon regulatory factor 3 in adaptive immune responses

被引：0
|
作者：
Laure Ysebrant de Lendonck
Valerie Martinet
Stanislas Goriely
机构：
[1] Université Libre de Bruxelles,WELBIO and Institute for Medical Immunology (IMI)
来源：
Cellular and Molecular Life Sciences | 2014年 / 71卷
关键词：
T cell differentiation; Type I IFNs; IL-12 family; CD8 T lymphocyte; Th17; TLR;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Interferon regulatory factor (IRF) 3 plays a key role in innate responses against viruses. Indeed, activation of this transcription factor triggers the expression of type I interferons and downstream interferon-stimulated genes in infected cells. Recent evidences indicate that this pathway also modulates adaptive immune responses. This review focuses on the different mechanisms that are implicated in this process. We discuss the role of IRF3 within antigen-presenting cells and T lymphocytes in the polarization of the cellular immune response and its implication in the pathogenesis of immune disorders.
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页码：3873 / 3883
页数：10
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