A Randomized, Placebo-Controlled Study to Investigate the Safety, Tolerability, and Pharmacokinetics of 3 Weeks of Orally Administered Gefapixant in Healthy Younger and Older Adults

被引:0
作者
Jesse Nussbaum
Azher Hussain
Anthony Ford
Peter Butera
Michael Kitt
Steve Smith
Aubrey Stoch
Marian Iwamoto
机构
[1] Merck & Co.,
[2] Inc.,undefined
来源
Lung | 2022年 / 200卷
关键词
Aged [MeSH]; Chronic cough; Gefapixant; Pharmacokinetics; Safety [MeSH]; Tolerability;
D O I
暂无
中图分类号
学科分类号
摘要
引用
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页码:315 / 323
页数:8
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[1]  
Çolak Y(2017)Risk factors for chronic cough among 14,669 individuals from the general population Chest 152 563-573
[2]  
Nordestgaard BG(2018)Classification of cough as a symptom in adults and management algorithms: CHEST guideline and expert panel report Chest 153 196-209
[3]  
Laursen LC(2019)Prevalence of chronic cough, patient characteristics and health outcomes among UK adults Eur Respir J 54 PA3327-4044.e2
[4]  
Irwin RS(2021)Prevalence and burden of chronic cough in the United States J Allergy Clin Immunol Pract 9 4037-408
[5]  
French CL(2015)The impact of chronic cough: a cross-sectional European survey Lung 193 401-60
[6]  
Chang AB(2007)Chronic cough from the patient's perspective Mayo Clin Proc 82 56-1714
[7]  
McGarvey L(2019)What is chronic cough? Terminology J Allergy Clin Immunol Pract 7 1711-919
[8]  
Morice A(2020)ERS guidelines on the diagnosis and treatment of chronic cough in adults and children Eur Respir J 55 1901136-4387
[9]  
Way N(2007)Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells Nat Med 13 913-L865
[10]  
Meltzer EO(2011)The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses J Immunol 186 4375-616