Immunomodulating properties of homo- and copolymers of N-vinylamides

被引：0
|
作者：
Panarin E.F. [1 ]
Ivanova N.P. [1 ]
Belokhvostova A.T. [2 ]
Potapenkova L.S. [2 ]
机构：
[1] Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg
[2] Petrov Institute of Oncology, Ministry of Public Health of the Russian Federation, St. Petersburg
来源：
Pharmaceutical Chemistry Journal | 2006年 / 40卷 / 3期
关键词：
AIBN; Vinyl Pyrrolidone; Copol; Methacryloyl; Glucosamine Hydrochloride;
D O I：
10.1007/s11094-006-0078-7
中图分类号：
学科分类号：
摘要：
A series of new water-soluble copolymers of methacrylamidoglucose (MAG) with N-vinylamides (N-vinylformamide and N-alkyl-N-vinylacetamides) have been synthesized and characterized as modulants in BALB/C mice (i.p. administration) and by the method of local gel hemolysis. The imunostimulant action was observed for poly(vinyl formamide) in a dose of 25, 10, and 5 mg/kg and for MAG copolymers with N-octyl-N-vinylacetamide in a dose of 50 and 10 mg/kg. The other copolymers did not exhibit significant activity. © 2006 Springer Science+Business Media, Inc.
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页码：141 / 144
页数：3
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