Histopathologic findings in women with postmenopausal bleeding: Implication for endometrial thickness and circulating levels of sex steroid hormones

被引：3
作者：
Yildirim M. [1 ]
Bozkurt N. [1 ]
Kurdoglu M. [2 ]
Taskiran C. [1 ]
Oktem M. [3 ]
Dilek K.U. [4 ]
机构：
[1] School of Medicine, Department of Gynecology and Obstetrics, Gazi University, Ankara, Tirebolu Sokak, 27/18, Yukariayranci
[2] Çankiri State Hospital, Gynecology and Obstetrics Clinic, Cankiri
[3] School of Medicine, Department of Gynecology and Obstetrics, Baskent University, Ankara
[4] School of Medicine, Department of Gynecology and Obstetrics, Mersin University, Mersin
来源：
Archives of Gynecology and Obstetrics | 2007年 / 276卷 / 4期
关键词：
Endometrial thickness; Postmenopausal bleeding; Sex hormones;
D O I：
10.1007/s00404-007-0361-1
中图分类号：
学科分类号：
摘要：
Objective: The aim of this study is to compare the relationship between estrone (E1), estradiol (E2), androgens, and prolactin blood levels on the one hand, and endometrial thickness and related histopathologic results on the other, in postmenopausal women admitted with uterine bleeding. Methods: The study was conducted in Gazi University School of Medicine, Obstetrics and Gynecology Clinic with a total of 128 patients. The study group consisted of 64 postmenopausal patients admitted with uterine bleeding, whereas the control group consisted of 64 healthy postmenopausal women. Vaginal sonography was performed to evaluate the endometrial thicknesses of the patients. Serum levels of free testosterone, androstenedione and estrone (E1) were determined by radioimmunoassay while serum estradiol (E2), prolactin, and dehydroepiandrosterone sulfate (DHEA-S) levels were evaluated by chemiluminescent method. Results: The median age, duration of menopause, menopausal age and gravidity, and parity did not differ between women with postmenopausal bleeding and the control group (P > 0.05). However, DHEA-S level was lower (P < 0.05) and endometrial thickness was greater in the study group than the control group (P < 0.05). Furthermore, the study identified that median endometrial thickness of the patients in atrophic endometrium group was less than the endometrial hyperplasia and endometrium carcinoma group (P < 0.05). Conclusion: In the current study, all these hormones seemed to be indifferent between groups of endometrial cancer and other pathological results. Based on our results regarding the safe margin of endometrial thickness in women with postmenopausal bleeding, it seems justifiable to refrain from curettage in patients with an endometrium of ≤4 mm. © 2007 Springer-Verlag.
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页码：305 / 310
页数：5
相关论文
共 25 条
  • [1] Fortier K.J., Postmenopausal bleeding and the endometrium, Clin Obstet Gynecol, 29, pp. 440-445, (1986)
  • [2] Siiteri P.K., Steroid hormones and endometrial cancer, Cancer Res, 38, pp. 4360-4366, (1978)
  • [3] Henderson B.E., Ross R.K., Pike M.C., Casagrande J.T., Endogenous hormones as a major factor in human cancer, Cancer Res, 42, pp. 3232-3239, (1982)
  • [4] Lukanova A., Lundin E., Micheli A., Arslan A., Ferrari P., Rinaldi S., Et al., Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women, Int J Cancer, 108, pp. 425-432, (2004)
  • [5] Yildirim M., Oktem M., Dilek T.U., Endometrial thickness and histopathologic findings in women with postmenopausal bleeding, Int J Gynaecol Obstet, 80, pp. 307-308, (2003)
  • [6] Speroff L., Fritz M.A., Clinical Gynecologic Endocrinology and Infertility, (2005)
  • [7] Dorfman R.I., Shipley R.A., Androgens, pp. 116-128, (1956)
  • [8] Horton R., Tait J.F., Androstenedione production and interconversion rates measured in peripheral blood and studies on the possible site of its conversion to testosterone, J Clin Invest, 45, pp. 301-313, (1966)
  • [9] Pang S., Riddick L., Hirsutism, Pediatric Endocrinology, a Clinical Guide, pp. 259-291, (1990)
  • [10] Vermeulen A., Androgen secretion by adrenals and gonads, Hirsutism and Virilism, pp. 17-34, (1983)
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