Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome?

被引：13

作者：

Conesa-Botella A. ^{[1
,3
]}

Mathieu C. ^{[2
]}

Colebunders R. ^{[1
,3
]}

Moreno-Reyes R. ^{[4
]}

van Etten E. ^{[2
]}

Lynen L. ^{[1
]}

Kestens L. ^{[5
]}

机构：

[1] Institute of Tropical Medicine, Department of Clinical Sciences, Antwerp

[2] Katholieke Universiteit Leuven, Laboratory of Experimental Medicine and Endocrinology, Leuven

[3] University of Antwerp, Faculty of Medicine, Antwerp

[4] Université Libre de Bruxelles, Department of Nuclear Medicine, Brussels

[5] Institute of Tropical Medicine, Department of Immunology, Antwerp

来源：

AIDS Research and Therapy | / 6卷 / 1期

关键词：

Human Immunodeficiency Virus; Immune Reconstitution Inflammatory Syndrome; Active Vitamin; Human Immunodeficiency Virus Infected Patient; Immune Restoration Disease;

D O I：

10.1186/1742-6405-6-4

中图分类号：

学科分类号：

摘要：

Background: About 20-30% of persons with HIV infection, especially those living in countries with limited resources, experience an immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral treatment. The active form of vitamin D, 1,25-dihydroxyvitamin D, is a key player in the clearance of pathogens and influences the level of inflammation and macrophage activation. Presentation of the hypothesis: We hypothesize that low availability of 1,25-dihydroxyvitamin D, either due to vitamin D deficiency or due to polymorphisms in the vitamin D receptor or in its activating/ inactivating enzymes, contributes to the appearance of IRIS. Furthermore, drug interactions with the enzymatic pathways of vitamin D could favour the development of IRIS. Testing the hypothesis: Our hypothesis could be explored by a case-control study to assess the prevalence of vitamin D deficiency in HIV-infected patients on antiretroviral treatment who develop and do not develop IRIS. Implications of the hypothesis: If the role of vitamin D in IRIS is confirmed, we would be able to screen patients at risk for IRIS by screening for vitamin D deficiency. After confirmation by means of a clinical trial, vitamin D supplementation could be a cheap and safe way to reduce the incidence of IRIS. © 2009 Conesa-Botella et al; licensee BioMed Central Ltd.

引用

共 46 条

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