Magnetic resonance imaging: Advanced applications in breast cancer

被引：0
作者：
Rahbar H. [1 ]
Kitsch A.E. [1 ]
Partridge S.C. [1 ]
机构：
[1] Breast Imaging Section, Department of Radiology, Seattle Cancer Care Alliance, University of Washington, 825 Eastlake Avenue East, P.O. Box 19023, Seattle, 98109–1023, WA
来源：
Current Radiology Reports | / 4卷 / 3期
基金：
美国国家卫生研究院;
关键词：
Breast cancer; Diffusion-weighted imaging; Dynamic contrast-enhanced PK modeling; Magnetic resonance spectroscopy; Multiparametric breast MRI;
D O I：
10.1007/s40134-016-0142-3
中图分类号：
学科分类号：
摘要：
Breast MRI is a highly sensitive imaging tool for breast cancer detection. In general clinical practice, breast MRI utilizes a limited dynamic contrast-enhanced (DCE) acquisition that provides morphologic and semiquantitative kinetic information to allow characterization of breast findings. This approach provides sensitivities approaching 100% for breast cancer detection; however, its specificity remains moderate due to limited ability to differentiate benign pathologic processes that enhance from malignancies. Several advanced MRI techniques, such as high-temporal resolution DCE that allows robust quantitative pharmacokinetic analysis, diffusion-weighted imaging that allows microstructural characterization, and MR spectroscopy that reflects chemical composition, hold promise to improve standard breast MRI specificity and to serve as imaging biomarkers that can guide treatment decisions. In this review article, we review recent updates in advanced breast MRI applications, including their potential clinical uses and challenges to implementation. © Springer Science+Business Media New York 2016.
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