Structure and Analgesic Activity of 13-(N-Aryl(N,N-Diethyl)Aminocarbonyl)-9-Methyl-11-Thioxo-8-Oxa-10,12-Diazatricyclo [7.3.1.02,7]Trideca-2,4,6-Trienes and Their 10-N-Phenyl Derivatives

被引：0
作者：
V. L. Gein
T. M. Zamaraeva
N. A. Buzmakova
I. P. Rudakova
M. V. Dmitriev
机构：
[1] Perm State Pharmaceutical Academy,
[2] Ministry of Health of the Russian Federation,undefined
[3] Perm State National Research University,undefined
来源：
Pharmaceutical Chemistry Journal | 2018年 / 52卷
关键词：
three-component reaction; -aryl(; ,; -diethyl)amides of acetoacetic acid; salicylaldehyde; thiourea; phenylthiourea; sodium bisulfate; 9-methyl-11-thioxo-8-oxa-10,12-diazatricyclo[7.3.1.0; ]trideca-2,4,6-trienes; x-ray crystal structure analysis; analgesic activity; acute toxicity;
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学科分类号：
摘要：
The structure and analgesic activity of 13-(N-aryl(N,N-diethyl)-aminocarbonyl)-9-methyl-11-thioxo-8-oxa-10,12-diazatricyclo[7.3.1.02,7]trideca-2,4,6-trienes and their 10-N-phenyl derivatives were studied. The studied compounds were shown to possess analgesic activity with low acute toxicity.
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页码：515 / 517
页数：2
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