Dendritic Cells Armed With Anti-CD3 mAbs Reduce Pulmonary Metastases, Prolong Survival, and Engender Antitumor Effector Cells Demonstrable by Adoptive Transfer

被引：0
作者：
Mary A. Maluccio
Jyosthna Rao
Vijay Sharma
Milagros Lagman
Manikkam Suthanthiran
机构：
[1] New York Presbyterian Hospital/Weill Medical College of Cornell University,Departments of Surgery
[2] New York Presbyterian Hospital/Weill Medical College of Cornell University,Departments of Medicine and Transplantation Medicine
来源：
Annals of Surgical Oncology | 2000年 / 7卷
关键词：
Tumor immunotherapy; Dendritic cells; Anti-CD3 mAbs.;
D O I：
暂无
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摘要：
Background: Dendritic cells (DCs) pulsed with tumor cells or peptides are effective antitumor agents in a number of tumor models. In light of our earlier demonstration that T-cell signaling via the CD3 proteins induces cytolytic activity and constrains tumor progression, we equipped DCs pulsed with tumor cells with anti-CD3 mAbs and tested their antitumor efficacy in a murine renal cell cancer pulmonary metastasis model.
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页码：771 / 776
页数：5
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