Conversion of vascular endothelial cells into multipotent stem-like cells

被引：0
作者：
Damian Medici
Eileen M Shore
Vitali Y Lounev
Frederick S Kaplan
Raghu Kalluri
Bjorn R Olsen
机构：
[1] Beth Israel Deaconess Medical Center,Division of Matrix Biology, Department of Medicine
[2] Harvard Medical School,Department of Orthopaedic Surgery
[3] University of Pennsylvania School of Medicine,Department of Genetics
[4] University of Pennsylvania School of Medicine,Department of Medicine
[5] Center for Research in Fibrodysplasia Ossificans Progressiva and Related Disorders,Department of Biological Chemistry and Molecular Pharmacology
[6] University of Pennsylvania School of Medicine,Department of Developmental Biology
[7] University of Pennsylvania School of Medicine,undefined
[8] Harvard Medical School,undefined
[9] Harvard–Massachusetts Institute of Technology Division of Health Sciences and Technology,undefined
[10] Harvard School of Dental Medicine,undefined
来源：
Nature Medicine | 2010年 / 16卷
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摘要：
Under certain conditions, endothelial cells can transform into mesenchymal cell types, a process known as endothelial-to-mesenchymal transition. Damian Medici et al. now provide evidence that this type of transition contributes to the generation of the ossified lesions of individuals with fibrodysplasia ossificans progressiva. Experiments in mice and in cultured endothelial cells indicate that activation of the ALK2 receptor in endothelial cells endows them with the ability to differentiate into a number of cell types.
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页码：1400 / 1406
页数：6
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