Effect of Hepatitis C Virus Coinfection on the Content of CD4+ and CD8+ T Cell Subpopulations in HIV-Infected Patients Receiving Antiretroviral Therapy

被引：0
|
作者：
L. B. Korolevskaya
K. V. Shmagel
E. V. Saidakova
N. G. Shmagel
S. V. Slobodchikova
V. A. Chereshnev
机构：
[1] Perm State National Research University,Institute of Ecology and Genetics of Microorganisms
[2] Ural Division of the Russian Academy of Sciences,Institute of Immunology and Physiology
[3] Perm Regional Center for Prevention of AIDS and Infectious Diseases,undefined
[4] Ural Division of the Russian Academy of Sciences,undefined
[5] Ural Federal University Named after the First President of Russia B. N. Yeltsin,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2016年 / 161卷
关键词：
HIV infection; HCV coinfection; antiretroviral therapy; T cell subpopulations;
D O I：
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中图分类号：
学科分类号：
摘要：
We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4+ T cells and an increase in the count of central CD8+ memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4+ memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.
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页码：281 / 283
页数：2
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