Effect of Hepatitis C Virus Coinfection on the Content of CD4+ and CD8+ T Cell Subpopulations in HIV-Infected Patients Receiving Antiretroviral Therapy

被引：0
|
作者：
L. B. Korolevskaya
K. V. Shmagel
E. V. Saidakova
N. G. Shmagel
S. V. Slobodchikova
V. A. Chereshnev
机构：
[1] Perm State National Research University,Institute of Ecology and Genetics of Microorganisms
[2] Ural Division of the Russian Academy of Sciences,Institute of Immunology and Physiology
[3] Perm Regional Center for Prevention of AIDS and Infectious Diseases,undefined
[4] Ural Division of the Russian Academy of Sciences,undefined
[5] Ural Federal University Named after the First President of Russia B. N. Yeltsin,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2016年 / 161卷
关键词：
HIV infection; HCV coinfection; antiretroviral therapy; T cell subpopulations;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4+ T cells and an increase in the count of central CD8+ memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4+ memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.
引用
收藏
页码：281 / 283
页数：2
相关论文
共 50 条
  • [21] Patterns of CD8 T cell clonal dominance in response to change in antiretroviral therapy in HIV-infected children
    Kharbanda, M
    Than, S
    Chitnis, V
    Sun, M
    Chavan, S
    Bakshi, S
    Pahwa, S
    AIDS, 2000, 14 (15) : 2229 - 2238
  • [22] Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function
    Fernandez, Sonia
    Price, Patricia
    McKinnon, Elizabeth J.
    Nolan, Richard C.
    French, Martyn A.
    CLINICAL IMMUNOLOGY, 2006, 120 (02) : 163 - 170
  • [23] Initiation of antiretroviral therapy at higher nadir CD4+ T-cell counts is associated with reduced arterial stiffness in HIV-infected individuals
    Ho, Jennifer E.
    Deeks, Steven G.
    Hecht, Frederick M.
    Xie, Yu
    Schnell, Amanda
    Martin, Jeffrey N.
    Ganz, Peter
    Hsue, Priscilla Y.
    AIDS, 2010, 24 (12) : 1897 - 1905
  • [24] CD4+:CD8+T Cell Ratio Normalization and the Development of AIDS Events in People with HIV Starting Antiretroviral Therapy
    Okhai, Hajra
    Vivancos-Gallego, Maria Jesus
    Hill, Teresa
    Sabin, Caroline A.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2020, 36 (10) : 808 - 816
  • [25] Periportal CD4+ Cell Infiltration Increases in HIV/Hepatitis C Virus-Coinfected Patients Commencing ART, Whereas CD8+ Cells Clear From the Liver
    Gani, Rino A.
    Yunihastuti, Evy
    Krisnuhoni, Ening
    Saraswati, Henny
    Djauzi, Sjamsurizal
    Lesmana, Laurentius A.
    Lee, Silvia
    Price, Patricia
    JOURNAL OF INFECTIOUS DISEASES, 2014, 210 (03) : 405 - 409
  • [26] Baseline Immune Phenotypes and CD4+ T Lymphocyte Responses to Antiretroviral Therapy in Younger versus Older HIV-infected Individuals
    Risa M. Hoffman
    Beth D. Jamieson
    Ronald J. Bosch
    Judith Currier
    Christina M. R. Kitchen
    Ingrid Schmid
    Yuda Zhu
    Kara Bennett
    Ronald Mitsuyasu
    Journal of Clinical Immunology, 2011, 31 : 873 - 881
  • [27] Approaches to antiretroviral therapy in HIV-infected patients with low CD4 lymphocyte counts
    Shakhgildyan, V. I.
    Yagodkin, M. V.
    TERAPEVTICHESKII ARKHIV, 2015, 87 (11) : 118 - 122
  • [28] Response to raltegravir-based salvage therapy in HIV-infected patients with hepatitis C virus or hepatitis B virus coinfection
    Weimer, Liliana Elena
    Fragola, Vincenzo
    Floridia, Marco
    Guaraldi, Giovanni
    Ladisa, Nicoletta
    Francisci, Daniela
    Bellagamba, Rita
    Degli Antoni, Anna
    Parruti, Giustino
    Giacometti, Andrea
    Manconi, Paolo Emilio
    Vivarelli, Angela
    D'Ettorre, Gabriella
    Mura, Maria Stella
    Cicalini, Stefania
    Preziosi, Roberta
    Sighinolfi, Laura
    Verucchi, Gabriella
    Libertone, Raffaella
    Tavio, Marcello
    Sarmati, Loredana
    Bucciardini, Raffaella
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2013, 68 (01) : 193 - 199
  • [29] Identification of CD8+ T cell subsets that normalize in early-treated people living with HIV receiving antiretroviral therapy
    Perdomo-Celis, Federico
    Arcia-Anaya, David
    Carlos Alzate, Juan
    Velilla, Paula A.
    Diaz, Francisco J.
    Paulina Posada, Maria
    Rugeles, Maria T.
    Taborda, Natalia A.
    AIDS RESEARCH AND THERAPY, 2022, 19 (01)
  • [30] Association of age at antiretroviral therapy initiation with CD4+: CD8+ ratio recovery among virally suppressed people with HIV
    Holden, Clare J.
    Lampe, Fiona C.
    Burns, Fiona M.
    Chaloner, Clinton
    Johnson, Margaret
    Kinloch-De Loes, Sabine
    Smith, Colette J.
    AIDS, 2024, 38 (05) : 703 - 711
12345