Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

被引：0
|
作者：
Souhila Medjkane
Cristina Perez-Sanchez
Cedric Gaggioli
Erik Sahai
Richard Treisman
机构：
[1] Transcription Laboratory,
[2] Cancer Research UK London Research Institute,undefined
[3] Lincoln's Inn Fields Laboratories,undefined
[4] 44 Lincoln's Inn Fields,undefined
[5] Tumour Biology Laboratory,undefined
[6] Cancer Research UK London Research Institute,undefined
[7] Lincoln's Inn Fields Laboratories,undefined
[8] 44 Lincoln's Inn Fields,undefined
[9] Oryzon Genomics,undefined
[10] C/ Josep Samitier 1-5,undefined
[11] UMR 7216 CNRS/Epigenetics and Cell Fate,undefined
[12] University Paris-Diderot,undefined
[13] 35 rue Hélèn Brion,undefined
[14] 75205 Paris cedex 13,undefined
[15] France,undefined
来源：
Nature Cell Biology | 2009年 / 11卷
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学科分类号：
摘要：
By preventing G-actin accumulation, Rho-GTPase promotes the transcriptional activity of myocardin-related transcription factors (MRTFs), known co-factors of serum response factor (SRF). Rho-dependent MRTF expression is required for injected metastatic cell lines to colonize the lung.
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页码：257 / 268
页数：11
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