Vitamin D deficiency exacerbates bleomycin-induced pulmonary fibrosis partially through aggravating TGF-β/Smad2/3-mediated epithelial-mesenchymal transition

被引:0
作者
Se-Ruo Li
Zhu-Xia Tan
Yuan-Hua Chen
Biao Hu
Cheng Zhang
Hua Wang
Hui Zhao
De-Xiang Xu
机构
[1] Anhui Medical University,Second Affiliated Hospital
[2] Anhui Medical University,Department of Toxicology
来源
Respiratory Research | / 20卷
关键词
Pulmonary fibrosis; Vitamin D deficiency; Epithelial-mesenchymal transition; Bleomycin; Mice;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 187 条
[1]  
Mora AL(2017)Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease Nat Rev Drug Discov 16 755-772
[2]  
Rojas M(2019)Developmental pathways in the pathogenesis of lung fibrosis Mol. Aspects. Med 65 56-69
[3]  
Pardo A(2017)Idiopathic pulmonary fibrosis Lancet. 389 1941-1952
[4]  
Selman M(1974)The pathogenesis of bleomycin-induced pulmonary fibrosis in mice Am. J. Pathol 77 185-197
[5]  
Chanda D(2015)Phenyl butyric acid inhibits epithelial-mesenchymal transition during bleomycin-induced lung fibrosis Toxicology Letters 232 213-220
[6]  
Otoupalova E(2015)Bleomycin in the setting of lung fibrosis induction: from biological mechanisms to counteractions Pharmacol Res 97 122-130
[7]  
Smith SR(2008)The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol 40 362-382
[8]  
Volckaert T(2011)Modeling pulmonary fibrosis with bleomycin Curr. Opin. Pulm. Med 17 355-361
[9]  
De Langhe SP(2018)Astragaloside IV modulates TGF-β1-dependent epithelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis J Cell Mol Med 22 4354-4365
[10]  
Thannickal VJ(2019)Tetraspanin 1 as a mediator of fibrosis inhibits EMT process and Smad2/3 and beta-catenin pathway in human pulmonary fibrosis J Cell Mol Med 23 3583-3596