Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma

被引：0
作者：
Satoshi Tanida
Hiromi Kataoka
Eiji Kubota
Yoshinori Mori
Makoto Sasaki
Naotaka Ogasawara
Tsuneya Wada
Tsutomu Mizoshita
Takaya Shimura
Kenji Murakami
Takashi Mizushima
Yoshikazu Hirata
Yasuyuki Okamoto
Motoshi Mabuchi
Masahide Ebi
Mamoru Tanaka
Takeshi Kamiya
Satoru Takahashi
Takashi Joh
机构：
[1] Nagoya City University Graduate School of Medical Sciences,Department of Gastroenterology and Metabolism
[2] Nagoya City University Graduate School of Medical Sciences,Department of Experimental Pathology and Tumor Biology
来源：
International Journal of Clinical Oncology | 2009年 / 14卷
关键词：
Malignant peritoneal mesothelioma; Gemcitabine; Cisplatin; Drug treatment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Malignant peritoneal mesothelioma is a rare neoplasm with a rapidly fatal course. The response of this disease to treatment is poor because it tends to be advanced at diagnosis and tends to have inherent resistance to chemotherapeutic treatment. We describe three patients with malignant peritoneal mesothelioma who received combination chemotherapy with cisplatin and gemcitabine. After a histopathological diagnosis of epithelial-type malignant peritoneal mesothelioma, all patients underwent systemic chemotherapy because of the advanced disease stage. Moreover, one patient would have been at high risk of cardiac events, because of congenital heart malformation if complete surgical resection had been performed. This chemotherapy achieved a partial response in two patients, but had no effect in one. Combination chemotherapy with cisplatin and gemcitabine may prove to be one of the recommended treatments for patients with malignant peritoneal mesothelioma in the near future.
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页码：266 / 269
页数：3
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