TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients

[1] Gardiner SJ(2000)Genetic polymorphism and outcomes with azathioprine and 6-mercaptopurine Adverse Drug React Toxicol Rev 19 293-312

[2] Begg EJ(2002)The thiopurine S-methyltransferase gene locus – implication for clinical pharmacogenomics Pharmacogenomics 3 89-98

[3] Barclay ML(1993)Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia Arch Dis Child 69 577-579

[4] Kirkpatrick CM(1996)Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms Pharmacogenetics 6 279-290

[5] McLeod HL(1980)Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity Am J Hum Genet 32 651-662

[6] Siva C(2007)Thiopurine S-methyltransferase (TPMT) pharmacogenetics: risk of genetically determined intolerance of thiopurine drugs in a Polish population Probl Ter Monitorowanej 18 21-27

[7] Lennard L(2006)Clinical pharmacogenomics of thiopurine S-methyltransferase Curr Clin Pharmacol 1 119-128

[8] Gibson BES(2008)Characterization of the inosine triphosphatase (ITPA) gene: haplotype structure, haplotype-phenotype correlation and promoter function Ther Drug Monit 30 16-22

[9] Nicole T(2002)Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency Hum Genet 111 360-367

[10] Lilleyman JS(2007)Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6 Ther Drug Monit 29 6-10

[1] Gardiner SJ(2000)Genetic polymorphism and outcomes with azathioprine and 6-mercaptopurine Adverse Drug React Toxicol Rev 19 293-312

[2] Begg EJ(2002)The thiopurine S-methyltransferase gene locus – implication for clinical pharmacogenomics Pharmacogenomics 3 89-98

[3] Barclay ML(1993)Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia Arch Dis Child 69 577-579

[4] Kirkpatrick CM(1996)Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms Pharmacogenetics 6 279-290

[5] McLeod HL(1980)Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity Am J Hum Genet 32 651-662

[6] Siva C(2007)Thiopurine S-methyltransferase (TPMT) pharmacogenetics: risk of genetically determined intolerance of thiopurine drugs in a Polish population Probl Ter Monitorowanej 18 21-27

[7] Lennard L(2006)Clinical pharmacogenomics of thiopurine S-methyltransferase Curr Clin Pharmacol 1 119-128

[8] Gibson BES(2008)Characterization of the inosine triphosphatase (ITPA) gene: haplotype structure, haplotype-phenotype correlation and promoter function Ther Drug Monit 30 16-22

[9] Nicole T(2002)Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency Hum Genet 111 360-367

[10] Lilleyman JS(2007)Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6 Ther Drug Monit 29 6-10