Insights into N6-methyladenosine and programmed cell death in cancer

被引：0
作者：
Li Liu
Hui Li
Dingyu Hu
Yanyan Wang
Wenjun Shao
Jing Zhong
Shudong Yang
Jing Liu
Ji Zhang
机构：
[1] Shenzhen Traditional Chinese Medicine Hospital,Department of Clinical Laboratory
[2] Hengyang Medical School,The First Affiliated Hospital, Department of Rheumatology
[3] University of South China,Hunan Province Key Laboratory of Basic and Applied Hematology, Molecular Biology Research Center & Center for Medical Genetics
[4] School of Life Sciences,Department of Dermatology, Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Clinical Research Center for Cancer Immunotherapy
[5] Central South University,undefined
[6] Xiangya Hospital,undefined
[7] Central South University,undefined
[8] The First Affiliated Hospital,undefined
[9] Department of Hematology,undefined
[10] Hengyang Medical School,undefined
[11] University of South Chinal,undefined
来源：
Molecular Cancer | / 21卷
关键词：
N6-methyladenosine; Cancer; Apoptosis; Autophagy; Pyroptosis; Ferroptosis; Necroptosis;
D O I：
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中图分类号：
学科分类号：
摘要：
N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years. M6A plays multifunctional roles in normal and abnormal biological processes, and its role may vary greatly depending on the position of the m6A motif. Programmed cell death (PCD) includes apoptosis, autophagy, pyroptosis, necroptosis and ferroptosis, most of which involve the breakdown of the plasma membrane. Based on the implications of m6A methylation on PCD, the regulators and functional roles of m6A methylation were comprehensively studied and reported. In this review, we focus on the high-complexity links between m6A and different types of PCD pathways, which are then closely associated with the initiation, progression and resistance of cancer. Herein, clarifying the relationship between m6A and PCD is of great significance to provide novel strategies for cancer treatment, and has a great potential prospect of clinical application.
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