Impact of depressive symptoms and hepatic encephalopathy on health-related quality of life in cirrhotic hepatitis C patients

被引：0
作者：
Katherine C. Barboza
Lilian M. Salinas
Farhad Sahebjam
Arun B. Jesudian
Ilan L. Weisberg
Samuel H. Sigal
机构：
[1] New York University Langone Medical Center,Department of Medicine
[2] New York University Langone Medical Center,Division of Gastroenterology, Department of Medicine
[3] New York University Langone Medical Center,Division of Gastroenterology, Department of Medicine
[4] New York Presbyterian Weill Cornell Medical Center,Center for Liver Disease and Transplantation
[5] New York University Langone Medical Center,Division of Gastroenterology, Department of Medicine
[6] New York University Langone Medical Center,Division of Gastroenterology, Department of Medicine
来源：
Metabolic Brain Disease | 2016年 / 31卷
关键词：
Cirrhosis; Depression; Fatigue; Health-Related Quality of Life; Hepatic Encephalopathy; Hepatitis C;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Depression, common in chronic medical conditions, and hepatic encephalopathy (HE), a reversible neuropsychiatric syndrome due to liver dysfunction, are associated with impaired health-related quality of life (HRQOL) in cirrhosis and hepatitis C (HCV). This study investigated the impact of depression and HE on HRQOL in cirrhotic patients with HCV. A convenience sample of 43 ambulatory patients, with varying degrees of cirrhosis secondary to HCV, was prospectively enrolled in this study. Participants were assessed for any current depressive, fatigue, and daytime sleepiness symptoms and underwent a psychometric evaluation to determine the presence of HE symptoms. Participants reported current HRQOL on general health and liver disease-specific questionnaires. Diagnosis and current health status were confirmed via medical records. The associations between disease severity, depressive symptoms, HE, fatigue, and daytime sleepiness were measured. Predictors of HRQOL in this sample were determined. Depressive symptoms (70 %) and HE (77 %) were highly prevalent in this sample, with 58 % actively experiencing both conditions at the time of study participation. A significant positive association was found between depressive symptoms and HE severity (P = .05). Depressive symptoms were significantly associated with fatigue (P < .001), daytime sleepiness (P < .001), general HRQOL (P < .001), and disease-specific HRQOL (P < .001). HE was significantly associated with fatigue (P = .02), general HRQOL (P < .001), and disease-specific HRQOL (P < .001). Depressive symptoms and HE were significant predictors of reduced HRQOL (P < .001), with depressive symptoms alone accounting for 58.8 % of the variance. Depressive symptoms and HE accounted for 68.0 % of the variance. Findings suggest a possible pathophysiological link between depression and HE in cirrhosis, and potentially a wider-reaching benefit of treating minimal and overt HE than previously appreciated.
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页码：869 / 880
页数：11
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  • [1] Ahluwalia V(2015)Correction of hyponatraemia improves cognition, quality of life, and brain oedema in cirrhosis J Hepatol 62 75-82
  • [2] Albrecht J(2010)Hepatic encephalopathy in our genes? Ann Intern Med 153 335-336
  • [3] Arguedas MR(2003)Influence of hepatic encephalopathy on health-related quality of life in patients with cirrhosis Dig Dis Sci 48 1622-1626
  • [4] DeLawrence TG(2006)The prevalence of hepatitis C virus infection in the United States, 1999 through 2002 Ann Intern Med 144 705-714
  • [5] McGuire BM(2012)Cognitive performance as a predictor of hepatic encephalopathy in pretransplant patients with cirrhosis receiving psychoactive medications: a prospective study Liver Transpl 18 1179-1187
  • [6] Armstrong GL(2014)Depression and chronic kidney disease: A review for clinicians Aust N Z J Psychiatry 48 530-541
  • [7] Wasley A(1997)Screening for major depression disorders in medical inpatients with the Beck Depression Inventory for Primary Care Behav Res Ther 35 785-791
  • [8] Simard EP(1989)Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy Neurochem Res 14 853-859
  • [9] McQuillan GM(2005)Psychological status and depression in patients with liver cirrhosis Dig Liver Dis 37 593-600
  • [10] Kuhnert WI(2008)Predictors for quality of life in continuous ambulatory peritoneal dialysis patients Nephrology 13 587-592
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