Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding

被引：0

作者：

Thomas Klitgaard

Rene Tabanera y Palacios

Kenneth D Boffard

Philip TC Iau

Brian Warren

Sandro Rizoli

Rolf Rossaint

Yoram Kluger

Bruno Riou

机构：

[1] Novo Nordisk A/S,Department of Biomodelling

[2] Novo Nordisk A/S,Department of Biostatistics

[3] ,Department of Surgery

[4] Johannesburg Hospital,Department of Surgery,National

[5] University Hospital,Department of Surgery

[6] Tygerberg Hospital,Departments of Surgery and Critical Care Medicine, Sunnybrook and Women's College Health Sciences Centre

[7] University of Stellenbosch,Department of Anesthesiology

[8] University of Toronto,Department of Surgery

[9] University Clinics,Department of Emergency Medicine and Surgery and Department of Anesthesiology and Critical Care, Hôpital Pitié

[10] Haifa Medical Center,Salpêtrière, Assistance Publique

[11] Université Pierre et Marie Curie-Paris 6,Hôpitaux de Paris;

来源：

Critical Care | / 10卷

关键词：

Trauma Patient; Population Pharmacokinetic Analysis; Coagulant Activity; Trauma Population; Intercompartmental Clearance;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 134 条

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[3] Hoffman M(1997)Platelet activity of high dose factor VIIa is independent of tissue factor Br J Haematol 99 542-547
[4] Monroe DM(2004)Recombinant factor VIIa: clinical applications for an intravenous haemostatic agent with broad-spectrum potential Expert Rev Cardiovasc Ther 2 661-674
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[6] Hoffman M(2004)Argatroban as anticoagulant in cardiopulmonary bypass in an infant and attempted reversal with recombinant activated factor VII Anesthesiology 101 1048-1049
[7] Oliver JA(2001)Recombinant activated factor VII for adjunctive hemorrhage control in trauma J Trauma 51 431-439
[8] Roberts HR(2004)Factor VIIa for correction of traumatic coagulopathy J Trauma 57 709-719
[9] Carr ME(2005)Recombinant coagulation factor VIIa in major liver resection: a randomized, placebo-controlled, double blind clinical trial Anesthesiology 102 269-275
[10] Martin EJ(2005)Recombinant Factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients. A randomized, placebo-controlled, double-blind clinical trial J Trauma 59 8-18