Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo

被引：0
作者：
Ditte Reker
Cecilie F. Kjelgaard-Petersen
Anne Sofie Siebuhr
Martin Michaelis
Anne Gigout
Morten A. Karsdal
Christoph Ladel
Anne C. Bay-Jensen
机构：
[1] Nordic Bioscience A/S,Biomarkers and Research Rheumatology
[2] Merck-KGaA,Osteoarthritis Research
[3] University of Copenhagen,Department of Biology
[4] Technical University of Denmark,undefined
来源：
Journal of Translational Medicine | / 15卷
关键词：
Osteoarthritis; Chondrocyte and cartilage biology; Other therapeutics;
D O I：
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摘要：
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  • [1] Power J(2014)Intra-articular injection of rhFGF-18 improves the healing in microfracture treated chondral defects in an ovine model J Orthop Res 32 669-676
  • [2] Hernandez P(2010)Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics of aggrecan and separated in time ex vivo Biomarkers 15 266-276
  • [3] Guehring H(2015)Age-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocytes Histol Histopathol 30 1-12
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