Physicochemical properties of high-molecular-weight plant polysaccharide of hexose glycoside class (Panavir) with antiviral activity

被引：4

作者：

Stovbun, S.V. ^{[1
]}

Berlin, A.A. ^{[1
]}

Mikhailov, A.I. ^{[1
]}

Sergienko, V.I. ^{[2
]}

Govorun, V.M. ^{[2
]}

Demina, I.A. ^{[2
]}

Kalinina, T.S. ^{[3
]}

机构：

[1] Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow 119991

[2] Research Institute of Physicochemical Medicine, Moscow 119435

[3] Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences

来源：

Nanotechnologies in Russia | 2012年 / 7卷 / 9-10期

关键词：

Glucose - Bioactivity - Antiviral agents;

D O I：

10.1134/S1995078012050138

中图分类号：

学科分类号：

摘要：

A high-molecular-weight plant polysaccharide belonging to the hexose glycoside (HG) class and composed of rhamnose (2-10%), arabinose (3-15%), glucose (10-67%), galactose (2-27%), xylose (0. 1-3%), and mannose (0. 1-5%) monosaccharides, as well as uronic acids (2-5%), had been isolated previously. It has high antiviral activity, as is proven by experimental models using hazardous and extremely dangerous viral infections such as herpes, cytomegalovirus, influenza, encephalitis, measles, rabies, and hepatitis C. The antiviral drug Panavir developed on its basis has an extremely low toxicity (LD 50 = 3000) and is an antiviral and immunomodulatory agent. There has been no microscopic (instead of phenomenological) model of its biological or pharmacological activity because of a lack of knowledge about its physicochemical nature. In the present work, the results of a study on the physicochemical properties of the HG macromolecules which makes it possible to qualitatively explain the biological activity and pharmacological properties of Panavir are presented. © 2012 Pleiades Publishing, Ltd.

引用

页码：539 / 543

页数：4

共 16 条

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