Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer

被引：0

作者：

Isabel Tundidor

Marta Seijo-Vila

Sandra Blasco-Benito

María Rubert-Hernández

Sandra Adámez

Clara Andradas

Sara Manzano

Isabel Álvarez-López

Cristina Sarasqueta

María Villa-Morales

Carmen González-Lois

Esther Ramírez-Medina

Belén Almoguera

Antonio J. Sánchez-López

Laura Bindila

Sigrid Hamann

Norbert Arnold

Christoph Röcken

Ignacio Heras-Murillo

David Sancho

Gema Moreno-Bueno

María M. Caffarel

Manuel Guzmán

Cristina Sánchez

Eduardo Pérez-Gómez

机构：

[1] Complutense University,Department of Biochemistry and Molecular Biology

[2] Instituto de Investigación Hospital 12 de Octubre,Brain Tumor Research Program

[3] Telethon Kids Institute,Centre for Child Health Research

[4] University of Western Australia,Breast Cancer Group, Oncology Area

[5] Biodonostia Health Research Institute,Gipuzkoa Cancer Unit

[6] OSI Donostialdea—Onkologikoa Foundation,Unit of Information and Healthcare Results, OSI Donostialdea

[7] Biodonostia Health Research Institute,Methodological Support Unit

[8] Biodonostia Health Research Institute,Department of Biology

[9] Centro de Biología Molecular Severo Ochoa (CBMSO) (CSIC-UAM),Department of Pathology

[10] Autonomous University of Madrid,Department of Obstetrics & Gynecology

[11] Hospital Universitario Puerta de Hierro,Clinical Lipidomics Unit, Institute of Physiological Chemistry

[12] Majadahonda,Department of Gynecology and Obstetrics

[13] Hospital Universitario Puerta de Hierro,Institute of Pathology

[14] Majadahonda,Immunobiology Laboratory

[15] Biobank Hospital Universitario Puerta de Hierro Majadahonda,MD Anderson International Foundation; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC

[16] Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana (IDIPHISA),UAM); Department of Biochemistry

[17] University Medical Center,undefined

[18] University Hospital Schleswig-Holstein,undefined

[19] University Hospital Schleswig-Holstein,undefined

[20] Centro Nacional de Investigaciones Cardiovasculares (CNIC),undefined

[21] Autonomous University of Madrid; Instituto de Investigación Hospital Universitario La Paz (IdiPaz); Centro de Investigación Biomédica en Red de Cáncer (CIBERONC),undefined

[22] Ikerbasque—Basque Foundation for Science,undefined

[23] Instituto Ramón y Cajal de Investigación Sanitaria y Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED),undefined

来源：

Nature Communications | / 14卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Clinical management of breast cancer (BC) metastasis remains an unmet need as it accounts for 90% of BC-associated mortality. Although the luminal subtype, which represents >70% of BC cases, is generally associated with a favorable outcome, it is susceptible to metastatic relapse as late as 15 years after treatment discontinuation. Seeking therapeutic approaches as well as screening tools to properly identify those patients with a higher risk of recurrence is therefore essential. Here, we report that the lipid-degrading enzyme fatty acid amide hydrolase (FAAH) is a predictor of long-term survival in patients with luminal BC, and that it blocks tumor progression and lung metastasis in cell and mouse models of BC. Together, our findings highlight the potential of FAAH as a biomarker with prognostic value in luminal BC and as a therapeutic target in metastatic disease.

引用