Renal cell carcinoma associated immunosuppressive therapy: a case report with Wegener’s granulomatosis

被引:0
作者
Serpil Muge Deger
Ruya Mutluay
Fatma Ayerden Ebinc
Turgay Arinsoy
Sukru Sindel
机构
[1] Gazi University,Department of Nephrology, Faculty of Medicine
来源
Rheumatology International | 2009年 / 30卷
关键词
Wegener’s granulomatosis (WG); Renal cell carcinoma (RCC); Cyclophosphamide; Azathioprine; Vasculitis;
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学科分类号
摘要
Development of uroepithelial tumors after cyclophosphamide and azathioprine therapy in Wegener’s granulomatosis (WG) have been reported in the literature but renal cell carcinoma (RCC), rarely. RCC associated with WG has been previously reported in a few cases. Most of them have simultaneous diseases. Here, we report a case, which developed RCC 8 years after initiation of WG. Long-term immunosuppressive treatment is a risk factor for the development of malignancies; it should be suggested that RCC in our patient might be due to immunosuppressive therapy.
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页码:119 / 121
页数:2
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[1]  
Hoffman GS(1992)Wegener granulomatosis: an analysis of 158 patients Ann Intern Med 116 488-498
[2]  
Kerr GS(1969)Hemorrhagic cystitis due to cyclophosphamide J Urol 101 45-852
[3]  
Leavitt RY(1998)Relaps rate, renal survival and cancer morbiditiy in patients with Wegener’s granulomatosis or microscopic polyangiitis with renal involvement J Am Soc Nephrol May 9 842-502
[4]  
Reynolds RD(1978)Malignancies associated with immunosuppressive or cytotoxic therapy Surgery 83 492-393
[5]  
Simerville JJ(1996)Renal cell carcinoma associated with cyclophosphamide therapy for wegener’s granulomatosis Scand J Rheumatol 25 391-44
[6]  
O’Hara DD(2003)A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies N Engl J Med 349 36-361
[7]  
Westman KWA(2006)Individualization of Immunosuppressive Therapy. III. Sirolimus associated with a reduced incidence of malignancy Transplant Proc 38 358-150
[8]  
Bygren PG(1996)Ulcerative colitis complicated by renal cell carcinoma: a series of three patients Gut January 38 148-25
[9]  
Olsson H(1993)An association between ANCA positive renal disease and malignancy Clin Nephrol 40 22-306
[10]  
Penn I(2002)Renal vasculitis associated with renal cell carcinoma J R Soc Med 95 305-458